Table 4.
Evolution (Δ) of iron concentration in the myocardium, liver (LIC) and pancreas (R2*) according to chelating therapy (n = 136).
|
Myocardium (Δ Fe mg.g/year) |
Combined deferiprone + deferrioxamine (n = 37) | Deferasirox (n = 32) | Deferiprone (n = 14) | Deferrioxamine (n = 53) |
|---|---|---|---|---|
| Mean (SD) | -0.125 (0.68) | -0.206 (0.54) | -0.077 (0.60) | -0.028 (0.63) |
| Median | -0.034 | -0.087 | 0.017 | -0.053 |
| Interquartile (25/75) | -0.358/0.121 | -0.315/0.092 | -0.315/0.092 | -0.239/0.303 |
| p-valuea | 0.685 | |||
| LIC (Δ Fe mg.g/year) | Combined deferiprone + deferrioxamine | Deferasirox | Deferiprone | Deferrioxamine |
| Mean (SD) | 0.311 (3.01) | -5.224 (12.02) | 0.568 (6.77) | 1.211 (5.65) |
| Median | 0.000 | -0.835 | -0.691 | -0.226 |
| Interquartile (25/75) | -1.252/1.261 | -2.615/1.297 | -1.591/-0.078 | -1.484/0.885 |
| p-valuea | 0.107 | |||
| Pancreas (R2* ΔHertz/year) | Combined deferiprone + deferrioxamine | Deferasirox | Deferiprone | Deferrioxamine |
| Mean (SD) | 19.364 (110.6) | -8.652 (63.3) | -4.496 (40.2) | -10.820 (80.3) |
| Median | -2.704 | -2.004 | 0.00000 | 0.246 |
| Interquartile (25/75) | -25.278/24.960 | -39.594/28.413 | -27.226/10.665 | -19.111/25.444 |
| p-valuea | 0.998 | |||
a
Kruskal-Wallis test.