Table 1.
DNA adducts putatively identified in BU-treated calf-thymus DNA and the blood DNA of patients receiving BU therapy
| [M + H]+ | tR (min) | NL | E. coli DNA (number of15N atoms) | Patient blood DNAa |
|---|---|---|---|---|
| 224.1135 | 8.6 | N | 5 | X |
| 257.0880 | 8.6 | dR | 5 | X |
| 262.0860 | 18.0 | C | – | X |
| 264.6485 | 8.3 | G | 5 | X |
| 290.1724 | 8.2 | G | 5 | X |
| 298.1430 | 28.9 | A | 5 | X |
| 300.1401 | 29.0 | A | 5 | X |
| 302.0920 | 16.0 | G | 5 | – |
| 306.1560 | 6.4 | dR | 5 | X |
| 316.1349 | 34.5 | G | 10 | – |
| 357.1531 | 9.6 | G | 10 | X |
| 358.1276 | 17.7 | dR | 5 | X |
| 378.1330 | 17.9 | dR | – | X |
| 418.1390 | 15.0 | dR | 5 | X |
| 432.1823 | 28.3 | dR | 7 | – |
| 441.2218 | 8.2 | G | 5 | X |
| 449.1726 | 15.6 | dR | 10 | X |
| 465.2080 | 49.7 | T | – | – |
| 469.1782 | 15.6 | dR | – | – |
| 482.2170 | 49.9 | T | – | – |
a
X indicates that adduct was detected in at least one patient.