Table 1.
All-cause mortality (n = 1162) | Heart disease (n = 475) | Cerebrovascular disease (n = 86) | Malignant neoplasms (n = 395) | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Predictor | β | SE | p | Hazard | β | SE | p | Hazard | β | SE | p | Hazard | β | SE | p | Hazard |
Ratio (95% CIs) | Ratio (95% CIs) | Ratio (95% CIs) | Ratio (95% CIs) | |||||||||||||
Age Spline-1 | −0.16 | 0.15 | 0.28 | 0.85 (0.63, 1.14) | −0.05 | 0.20 | 0.82 | 0.96 (0.64, 1.42) | −0.04 | 0.31 | 0.89 | 0.96 (0.52, 1.75) | −0.05 | 0.19 | 0.80 | 0.95 (0.66, 1.38) |
Age Spline-2 | 0.10 | 0.34 | 0.76 | 1.11 (0.57, 2.14) | −0.11 | 0.44 | 0.79 | 0.89 (0.38, 2.10) | 0.12 | 0.67 | 0.86 | 1.13 (0.30, 4.22) | −0.22 | 0.37 | 0.56 | 0.80 (0.39, 1.66) |
Age Spline-3 | 3.77 | 0.37 | <0.001*** | 43.31 (20.97, 89.44) | 4.25 | 0.52 | <0.001*** | 70.17 (25.36, 194.20) | 2.73 | 0.99 | 0.01** | 15.35 (2.22, 106.03) | 4.88 | 0.52 | <0.001*** | 131.97 (47.23, 368.80) |
Testosterone | −0.06 | 0.03 | 0.048* | 0.94 (0.88, 0.99) | −0.15 | 0.05 | 0.01** | 0.86 (0.78, 0.96) | −0.38 | 0.12 | 0.002** | 0.68 (0.54, 0.86) | 0.04 | 0.03 | 0.12 | 1.04 (0.99, 1.10) |
African American | −0.41 | 0.14 | 0.004** | 0.67 (0.51, 0.87) | −0.26 | 0.16 | 0.11 | 0.77 (0.57, 1.06) | 0.03 | 0.40 | 0.95 | 1.03 (0.47, 2.25) | −0.64 | 0.25 | 0.01* | 0.53 (0.32, 0.87) |
Other Ethnicity | −0.81 | 0.22 | <0.001*** | 0.45 (0.29, 0.69) | −0.99 | 0.40 | 0.02* | 0.37 (0.17, 0.81) | −0.73 | 0.69 | 0.30 | 0.48 (0.12, 1.87) | −0.83 | 0.43 | 0.06† | 0.44 (0.19, 1.01) |
Hispanic/Latino | −0.03 | 0.13 | 0.80 | 0.97 (0.75, 1.25) | 0.06 | 0.22 | 0.78 | 1.06 (0.69, 1.64) | 0.01 | 0.44 | 0.98 | 1.01 (0.43, 2.37) | -0.09 | 0.20 | 0.65 | 0.91 (0.61, 1.36) |
Education | −0.43 | 0.07 | <0.001*** | 0.65 (0.56, 0.75) | −0.51 | 0.12 | <0.001*** | 0.60 (0.47, 0.76) | −0.38 | 0.18 | 0.04* | 0.68 (0.48, 0.97) | −0.39 | 0.09 | <0.001*** | 0.68 (0.57, 0.81) |
Body Mass Index | −0.02 | 0.01 | 0.047* | 0.98 (0.96, 0.99) | −0.01 | 0.02 | 0.61 | 0.99 (0.96, 1.02) | −0.13 | 0.05 | 0.02* | 0.88 (0.80, 0.97) | −0.04 | 0.02 | 0.03* | 0.96 (0.93, 1.00) |
Age 1*Testosterone | −0.03 | 0.03 | 0.39 | 0.97 (0.91, 1.04) | −0.06 | 0.05 | 0.22 | 0.94 (0.86, 1.03) | −0.10 | 0.07 | 0.19 | 0.91 (0.79, 1.05) | −0.05 | 0.04 | 0.21 | 0.96 (0.89, 1.03) |
Age 2*Testosterone | 0.13 | 0.07 | 0.07 | 1.14 (0.99, 1.31) | 0.15 | 0.10 | 0.14 | 1.16 (0.95, 1.42) | 0.21 | 0.14 | 0.13 | 1.23 (0.94, 1.62) | 0.21 | 0.07 | 0.003** | 1.23 (1.08, 1.40) |
Age 3*Testosterone | −0.31 | 0.08 | <0.001*** | 0.73 (0.63, 0.85) | −0.34 | 0.12 | 0.01** | 0.71 (0.57, 0.90) | 0.05 | 0.17 | 0.77 | 1.05 (0.76, 1.46) | −0.55 | 0.11 | <0.001*** | 0.57 (0.46, 0.72) |
Note: Lower testosterone levels are associated with higher risk of death in men.
*p < 0.05, **p < 0.01, ***p < 0.001, †p < 0.06.