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. 2022 Dec 26;11(1):30–41. doi: 10.1093/emph/eoac044

Table 1.

Results of discrete-time hazard models for all-cause mortality, heart diseases, cardiovascular diseases and malignant neoplasms

All-cause mortality (n = 1162) Heart disease (n = 475) Cerebrovascular disease (n = 86) Malignant neoplasms (n = 395)
Predictor β SE p Hazard β SE p Hazard β SE p Hazard β SE p Hazard
Ratio (95% CIs) Ratio (95% CIs) Ratio (95% CIs) Ratio (95% CIs)
Age Spline-1 −0.16 0.15 0.28 0.85 (0.63, 1.14) −0.05 0.20 0.82 0.96 (0.64, 1.42) −0.04 0.31 0.89 0.96 (0.52, 1.75) −0.05 0.19 0.80 0.95 (0.66, 1.38)
Age Spline-2 0.10 0.34 0.76 1.11 (0.57, 2.14) −0.11 0.44 0.79 0.89 (0.38, 2.10) 0.12 0.67 0.86 1.13 (0.30, 4.22) −0.22 0.37 0.56 0.80 (0.39, 1.66)
Age Spline-3 3.77 0.37 <0.001*** 43.31 (20.97, 89.44) 4.25 0.52 <0.001*** 70.17 (25.36, 194.20) 2.73 0.99 0.01** 15.35 (2.22, 106.03) 4.88 0.52 <0.001*** 131.97 (47.23, 368.80)
Testosterone −0.06 0.03 0.048* 0.94 (0.88, 0.99) −0.15 0.05 0.01** 0.86 (0.78, 0.96) −0.38 0.12 0.002** 0.68 (0.54, 0.86) 0.04 0.03 0.12 1.04 (0.99, 1.10)
African American −0.41 0.14 0.004** 0.67 (0.51, 0.87) −0.26 0.16 0.11 0.77 (0.57, 1.06) 0.03 0.40 0.95 1.03 (0.47, 2.25) −0.64 0.25 0.01* 0.53 (0.32, 0.87)
Other Ethnicity −0.81 0.22 <0.001*** 0.45 (0.29, 0.69) −0.99 0.40 0.02* 0.37 (0.17, 0.81) −0.73 0.69 0.30 0.48 (0.12, 1.87) −0.83 0.43 0.06† 0.44 (0.19, 1.01)
Hispanic/Latino −0.03 0.13 0.80 0.97 (0.75, 1.25) 0.06 0.22 0.78 1.06 (0.69, 1.64) 0.01 0.44 0.98 1.01 (0.43, 2.37) -0.09 0.20 0.65 0.91 (0.61, 1.36)
Education −0.43 0.07 <0.001*** 0.65 (0.56, 0.75) −0.51 0.12 <0.001*** 0.60 (0.47, 0.76) −0.38 0.18 0.04* 0.68 (0.48, 0.97) −0.39 0.09 <0.001*** 0.68 (0.57, 0.81)
Body Mass Index −0.02 0.01 0.047* 0.98 (0.96, 0.99) −0.01 0.02 0.61 0.99 (0.96, 1.02) −0.13 0.05 0.02* 0.88 (0.80, 0.97) −0.04 0.02 0.03* 0.96 (0.93, 1.00)
Age 1*Testosterone −0.03 0.03 0.39 0.97 (0.91, 1.04) −0.06 0.05 0.22 0.94 (0.86, 1.03) −0.10 0.07 0.19 0.91 (0.79, 1.05) −0.05 0.04 0.21 0.96 (0.89, 1.03)
Age 2*Testosterone 0.13 0.07 0.07 1.14 (0.99, 1.31) 0.15 0.10 0.14 1.16 (0.95, 1.42) 0.21 0.14 0.13 1.23 (0.94, 1.62) 0.21 0.07 0.003** 1.23 (1.08, 1.40)
Age 3*Testosterone −0.31 0.08 <0.001*** 0.73 (0.63, 0.85) −0.34 0.12 0.01** 0.71 (0.57, 0.90) 0.05 0.17 0.77 1.05 (0.76, 1.46) −0.55 0.11 <0.001*** 0.57 (0.46, 0.72)

Note: Lower testosterone levels are associated with higher risk of death in men.

*p < 0.05, **p < 0.01, ***p < 0.001, †p < 0.06.