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. 2022 Dec 26;11(1):30–41. doi: 10.1093/emph/eoac044

Table 2.

Results of discrete-time hazard models for influenza and pneumonia, chronic lower respiratory diseases and Alzheimer’s disease

Influenza and pneumonia (n = 29) Chronic lower respiratory disease (n = 66) Alzheimer’s disease (n = 38)
Predictor β SE p Hazard β SE< p Hazard β SE p Hazard
ratio (95% CIs) ratio (95% CIs) ratio (95% CIs)
Age Spline-1 0.20 0.39 0.60 1.22 (0.57, 2.63) 0.15 0.46 0.74 1.17 (0.47, 2.89) 0.49 0.26 0.07 1.63 (0.97, 2.71)
Age Spline-2 −1.04 0.69 0.13 0.35 (0.09, 1.35) −0.05 1.20 0.96 0.95 (0.09, 9.88) −0.95 0.61 0.12 0.39 (0.12, 1.27)
Age Spline-3 6.02 0.93 <0.001*** 410.76 (66.20, 2548.82) 2.50 1.75 0.16 12.19 (0.40, 374.64) 4.64 0.89 <0.001*** 103.60 (17.94, 598.22)
Testosterone −0.06 0.10 0.54 0.94 (0.77, 1.15) −0.23 0.13 0.09 0.80 (0.61, 1.03) −0.21 0.11 0.05† 0.81 (0.66, 1.00)
African American −0.02 0.51 0.97 0.98 (0.36, 2.65) −1.49 0.51 0.005** 0.22 (0.08, 0.61) −1.76 0.64 0.01** 0.17 (0.05, 0.60)
Other Ethnicity 0.27 0.89 0.76 1.31 (0.23, 7.46) 0.08 0.56 0.88 1.09 (0.37, 3.24) −15.43 0.20 <0.001*** 0.00 (0.00, 0.00)
Hispanic/Latino 0.29 0.68 0.67 1.33 (0.35, 5.05) 0.23 0.42 0.59 1.25 (0.56, 2.83) −0.40 0.57 0.48 0.67 (0.22, 2.05)
Education −0.58 0.25 0.02* 0.56 (0.34, 0.92) −0.61 0.18 <0.001*** 0.54 (0.38, 0.77) −0.25 0.23 0.29 0.78 (0.49, 1.23)
Body Mass Index 0.01 0.04 0.84 1.01 (0.94, 1.08) 0.03 0.05 0.49 1.03 (0.94, 1.14) −0.12 0.04 0.01** 0.89 (0.82, 0.97)
Age 1*Testosterone −0.16 0.08 0.06† 0.85 (0.73, 1.00) −0.14 0.08 0.09 0.87 (0.75, 1.02) −0.22 0.05 <0.001*** 0.81 (0.73, 0.89)
Age 2*Testosterone 0.49 0.16 0.004** 1.62 (1.18, 2.24) 0.23 0.21 0.29 1.26 (0.83, 1.91) 0.38 0.12 0.002** 1.46 (1.16, 1.85)
Age 3*Testosterone −0.74 0.25 0.005** 0.48 (0.29, 0.78) 0.08 0.34 0.82 1.08 (0.55, 2.11) −0.18 0.17 0.27 0.83 (0.60, 1.15)

Note. Lower testosterone levels are associated with higher risk of death in men.

*p < 0.05, **p < 0.01, ***p < 0.001, †p < 0.06.