Table 2.

Top differentially methylated CpGs between female African American patients with SSc and controls ranked by absolute effect size

CpG	Gene	Chr	Position (kb)	Relation to Island	Control β	SSc β	Difference	p value	Adjusted p value
cg22805491	NIN	14	51,172	OpenSea	0.44	0.53	0.09	2.99E−08	0.02
cg24073653	SLC41A2	12	105,221	OpenSea	0.61	0.69	0.08	2.92E−06	0.2
cg19933320	ZNF107	7	64,125	N_Shore	0.33	0.4	0.08	8.20E−06	0.35
cg06548512	LOC728989	1	146,522	Island	0.63	0.7	0.07	1.32E−07	0.05
cg00832928	SELENOT	3	150,329	Island	0.61	0.68	0.07	4.58E−07	0.11
cg08653580	CD5	11	60,862	OpenSea	0.66	0.73	0.07	1.21E−06	0.16
cg12601237	ST8SIA6	10	17,429	OpenSea	0.71	0.78	0.07	3.69E−06	0.21
cg14115740	FANCC	9	98,055	Island	0.57	0.64	0.07	4.74E−06	0.24
cg22167498	RAB11B-AS1	19	8451	N_Shelf	0.57	0.62	0.06	1.00E−06	0.16
cg23596249	MARCHF1	4	165,110	Island	0.51	0.57	0.06	1.85E−06	0.19
cg13704629	DCAF4	14	73,396	S_Shelf	0.56	0.62	0.06	2.73E−06	0.2
cg11652329	P2RX6P	22	21,399	N_Shore	0.61	0.67	0.05	4.74E−06	0.24
cg26715639	S100A11	1	151,986	OpenSea	0.6	0.65	0.05	6.43E−06	0.31
cg23493751	CCR3	3	46,205	OpenSea	0.75	0.8	0.05	7.64E−06	0.34
cg08288426	ZSCAN29	15	43,651	OpenSea	0.8	0.76	− 0.04	1.51E−06	0.17
cg18507060	OAS3	12	113,399	OpenSea	0.77	0.81	0.04	5.48E−07	0.11
cg10044900	CFAP44	3	113,058	OpenSea	0.76	0.8	0.04	2.55E−06	0.2
cg14929421	ACTR3BP2	2	92,318	OpenSea	0.52	0.55	0.03	2.80E−06	0.2
cg04331667	CCDC71L	7	106,171	OpenSea	0.8	0.83	0.03	3.21E−06	0.2

CpGs are shown, along with nearest gene, annotation, averaged methylation levels (β), methylation difference, unadjusted and adjusted p values