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. 2023 Feb 18;16:8. doi: 10.1186/s13072-023-00481-y

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — A subset of KDM5 interactors are implicated in neurodevelopmental disorders. A Overlap between human orthologs of Drosophila KDM5 interactors and genes associated with ASD using the SFARI database. S indicates syndromic ASD. Scores indicate confidence of causal association, with 1 indicating strongest link. B 26 candidate interacting proteins identified and their SFARI score. C 24 candidate interacting proteins were identified as being implicated in ID, ASD and/or schizophrenia using DBD. D Model for KDM5 interactions with key transcriptional proteins that are likely to impact the expression of downstream target genes