Fig. 1.

Modifier genes in models and molecular pathways. A A histogram of the number of target genes (Y-axis) whose predicted essentiality (X-axis) is correlated with its actual essentiality, in the test set. Blue and red bars correspond to using an unrestricted number of modifier genes (in the predictive model, blue), or when restricting the predictions to a single modifier gene (mostly correlated, red). As can be seen, single-gene models offer lower accuracy compared to larger sets of modifier genes. B A bar plot of − log10 transformed p-values of the five most significant pathway annotations in KEGG human database [16] for the modifier genes/selected feature of WRAP73 gene