Table 1.
GO enrichment analysis of DEGs from uterine fluid samples
| Category | Term | Gene count | p-value | Fold Enrichment | FDR |
|---|---|---|---|---|---|
| Biological Process | GO:0007165 ~ signal transduction | 83 | 2.92E-05 | 1.59 | 0.05 |
| GO:0045944 ~ positive regulation of transcription from RNA polymerase II promoter | 60 | 1.40E-02 | 1.36 | 22.49 | |
| GO:0000122 ~ negative regulation of transcription from RNA polymerase II promoter | 50 | 2.60E-03 | 1.54 | 4.61 | |
| GO:0045893 ~ positive regulation of transcription, DNA-templated | 39 | 1.98E-03 | 1.68 | 3.53 | |
| GO:0006357 ~ regulation of transcription from RNA polymerase II promoter | 36 | 8.56E-04 | 1.81 | 1.54 | |
| GO:0006954 ~ inflammatory response | 26 | 3.67E-02 | 1.52 | 49.24 | |
| GO:0043065 ~ positive regulation of apoptotic process | 24 | 9.19E-03 | 1.77 | 15.42 | |
| GO:0050900 ~ leukocyte migration | 21 | 5.05E-07 | 3.82 | 0.00 | |
| GO:0001525 ~ angiogenesis | 21 | 2.68E-03 | 2.09 | 4.75 | |
| GO:0008360 ~ regulation of cell shape | 18 | 1.87E-04 | 2.85 | 0.34 | |
| Cellular Component | GO:0005737 ~ cytoplasm | 298 | 7.41E-08 | 1.30 | 0.00 |
| GO:0005634 ~ nucleus | 270 | 8.01E-03 | 1.13 | 10.94 | |
| GO:0005829 ~ cytosol | 200 | 8.78E-07 | 1.37 | 0.00 | |
| GO:0070062 ~ extracellular exosome | 183 | 1.55E-08 | 1.48 | 0.00 | |
| GO:0005654 ~ nucleoplasm | 157 | 5.89E-04 | 1.28 | 0.85 | |
| GO:0016020 ~ membrane | 146 | 2.40E-07 | 1.51 | 0.00 | |
| GO:0005739 ~ mitochondrion | 81 | 2.41E-03 | 1.38 | 3.42 | |
| GO:0005615 ~ extracellular space | 75 | 2.61E-02 | 1.27 | 31.66 | |
| GO:0048471 ~ perinuclear region of cytoplasm | 38 | 3.75E-02 | 1.39 | 42.34 | |
| GO:0009986 ~ cell surface | 34 | 3.70E-02 | 1.43 | 41.92 | |
| Molecular Function | GO:0005515 ~ protein binding | 492 | 2.66E-12 | 1.23 | 0.00 |
| GO:0044822 ~ poly(A) RNA binding | 72 | 3.03E-03 | 1.41 | 4.64 | |
| GO:0008270 ~ zinc ion binding | 66 | 4.84E-02 | 1.24 | 54.05 | |
| GO:0042803 ~ protein homodimerization activity | 46 | 2.32E-02 | 1.39 | 30.79 | |
| GO:0043565 ~ sequence-specific DNA binding | 33 | 4.91E-02 | 1.40 | 54.63 | |
| GO:0003682 ~ chromatin binding | 32 | 1.88E-03 | 1.80 | 2.90 | |
| GO:0005102 ~ receptor binding | 27 | 1.07E-02 | 1.69 | 15.49 | |
| GO:0003779 ~ actin binding | 26 | 9.10E-04 | 2.06 | 1.42 | |
| GO:0008134 ~ transcription factor binding | 26 | 1.23E-03 | 2.02 | 1.90 | |
| GO:0044212 ~ transcription regulatory region DNA binding | 17 | 3.33E-02 | 1.76 | 41.17 |