Table 3.

Difference of Sex-Related Hormones Across Tertiles of BMD T-Score in L2-4, FN, and TH in Men and Postmenopausal Women T2DM Patients

	Men (n = 149)				Postmenopausal Women (n = 102)
	Tertile 1	Tertile 2	Tertile 3	P value	Tertile 1	Tertile 2	Tertile 3	P value
Lumbar 2–4 (L2-4)
T-score of BMD	≤0.937	0.945–1.039	≥1.044		≤0.812	0.813–0.938	≥0.947
Estradiol (E2, pmol/L)	81.9±35.7	99.8±37.1	121.6±29.4	<0.001*	18.4 (18.4–22.3)	25.4 (18.4–40.5)	18.4 (18.4–31.3)	0.472
Luteinizing hormone (LH, mIU/mL)	6.8 (5.3–8.7)	7.6 (6.4–10.1)	8.5 (6.9–12.5)	0.424	30.4±15.1	29.3±13.1	33.6±16.3	0.689
FSH (mIU/mL)	8.2 (6.4–12.5)	8.3 (5.8–11.5)	9.4 (6.6–13.8)	0.428	57.1 (44.5–70.9)	50.9 (38.6–60.3)	52.3 (43.7–66.9)	0.918
Progesterone (nmol/L)	0.4 (0.2–0.6)	0.3 (0.2–0.5)	0.4 (0.2–0.6)	0.106	0.4 (0.2–0.6)	0.3 (0.2–0.6)	0.3 (0.2–0.5)	0.356
Total testosterone (nmol/L)	13.74±5.84	14.25±5.46	16.15±4.64	0.023*	0.4 (0.2–0.6)	0.4 (0.1–0.7)	0.4 (0.3–0.7)	0.487
Prolactin (PRL, mIU/L)	264.9 (211.6–382.8)	268.6 (177.8–462.6)	289.6 (206.3–402.8)	0.059	328.8 (251.8–444.9)	329.8 (248.7–411.6)	313.6 (242.9–361.1)	0.469
Femoral neck
T-score of BMD	≤0.722	0.728–0.824	≥0.826		≤0.618	0.622–0.709	≥0.712
Estradiol (E2, pmol/L)	90.7±37.7	96.6±37.7	116.070±32.874	0.002*	18.4 (18.4–32.8)	18.4 (18.4–23.9)	22.8 (18.4–40.5)	0.873
Luteinizing hormone (LH, mIU/mL)	7.6 (6.3–9.0)	7.7 (6.1–10.4)	7.8 (6.4–11.1)	0.709	29.1±14.1	32.1±17.1	30.9±13.6	0.720
FSH (mIU/mL)	9.1 (6.9–13.2)	8.6 (6.3–11.3)	7.7 (4.6–12.3)	0.420	59.8 (47.9–76.3)	57.1 (39.5–69.9)	47.6 (39.1–55.9)	0.509
Progesterone (nmol/L)	0.4 (0.2–0.6)	0.4 (0.2–0.5)	0.4 (0.3–0.6)	0.247	0.3 (0.2–0.4)	0.3 (0.2–0.5)	0.3 (0.2–0.6)	0.811
Total testosterone (nmol/L)	15.4±6.1	13.5±4.8	15.4±5.2	0.121	0.3 (0.1–0.7)	0.4 (0.1–0.7)	0.5 (0.3–0.8)	0.691
Prolactin (PRL, mIU/L)	278.0 (223.3–432.2)	263.9 (175.7–418.0)	288.4 (239.5–382.8)	0.417	302.7 (208.7–375.1)	350.8 (290.2–414.3)	328.3 (251.0–406.0)	0.515
Total Hip
T-score of BMD	≤0.864	0.865–0.984	≥0.985		≤0.736	0.739–0.855	≥0.857
Estradiol (E2, pmol/L)	89.3±39.4	95.5±32.0	118.27±34.7	<0.001*	18.4 (18.4–32.8)	18.4 (18.4–20.8)	24.7 (18.4–40.5)	0.964
Luteinizing hormone (LH, mIU/mL)	7.7 (6.2–10.5)	7.0 (5.5–9.5)	8.2 (6.8–9.8)	0.157	30.6±15.6	30.7±15.5	30.9±13.9	1.000
FSH (mIU/mL)	8.8 (6.7–13.1)	8.3 (6.2–11.3)	8.2 (4.8–11.9)	0.436	58.8 (44.8–75.3)	59.3 (43.5–69.3)	47.6 (39.1–55.9)	0.355
Progesterone (nmol/L)	0.4 (0.2–0.6)	0.4 (0.2–0.6)	0.4 (0.192–0.5)	0.994	0.3 (0.2–0.5)	0.3 (0.2–0.5)	0.2 (0.2–0.4)	0.981
Total testosterone (nmol/L)	14.8±5.6	14.3±5.4	15.1±5.3	0.791	0.4 (0.1–0.7)	0.4 (0.2–0.7)	0.5 (0.3–0.8)	0.678
Prolactin (PRL, mIU/L)	289.4 (220.8–427.5)	286.5 (208.0–463.2)	265.9 (205.4–349.1)	0.696	329.8 (236.1–381.8)	328.3 (248.7–411.6)	328.8 (271.9–406.6)	0.123
Minimum T-score of any site
T-score of BMD	≤-1.9	−1.8 ~ −1.1	≥-1.0		≤-2.5	−2.4 ~ −1.7	≥-1.6
Estradiol (E2, pmol/L)	85.0±37.2	100.9±36.8	117.8±32.3	<0.001*	18.4 (18.4–30.6)	18.4 (18.4–30.5)	22.3 (18.4–33.5)	0.142
Luteinizing hormone (LH, mIU/mL)	14.5±5.9	14.4±5.1	15.4±5.2	0.603	0.3 (0.1–0.6)	0.4 (0.2–0.7)	0.6 (0.3–0.8)	0.111
FSH (mIU/mL)	0.4 (0.2–0.6)	0.3 (0.2–0.5)	0.4 (0.2–0.6)	0.348	0.2 (0.2–0.4)	0.4 (0.2–0.6)	0.3 (0.2–0.6)	0.112
Progesterone (nmol/L)	7.0 (5.6–8.9)	7.7 (6.5–9.8)	8.5 (6.7–12.9)	0.079	32.8±13.4	30.7±14.9	29.5±16.4	0.655
Total testosterone (nmol/L)	8.2 (6.4–12.6)	8.9 (6.3–11.6)	8.3 (4.8–12.9)	0.421	60.8 (50.0–73.9)	53.8 (41.8–70.9)	46.0 (38.9–56.7)	0.365
Prolactin (PRL, mIU/L)	253.3 (195.9–343.7)	288.7 (211.9–450.1)	287.4 (214.4–398.9)	0.176	312.5 (236.1–363.2)	349.9 (263.5–453.7)	311.5 (249.3–393.7)	0.349

Note: * p<0.05.