Table 4.

Regression Coefficients of Multivariable Linear Regression of Estradiol (E2) for Indices of BMD in Men, Postmenopausal Women and All T2DM Patients

Sites	Unadjusted Regression Coefficient			Adjusted Regression Coefficient
	Beta	SE	P value	Beta	SE	P value
Men (n = 149)†
Lumbar 2–4 (L2-4) T-score	0.001	0.000	<0.001*	0.001	0.000	0.001*
Femoral neck T-score	0.001	0.000	<0.001*	0.001	0.000	0.002*
Total hip T-score	0.001	0.000	0.001	0.001	0.000	0.004*
Minimum T-score	0.009	0.002	<0.001*	0.009	0.002	<0.001*
FRAX MOF	−0.007	0.003	0.007*	−0.009	0.003	0.002*
FRAX HF	−0.006	0.002	0.005*	−0.007	0.002	0.001
Postmenopausal Women (n = 102)†
Lumbar 2–4 (L2-4) T-score	0.001	0.001	0.015*	0.002	0.001	0.006*
Femoral neck T-score	0.001	0.000	0.062	0.000	0.000	0.536
Total hip T-score	0.001	0.000	0.017*	0.001	0.000	0.102
Minimum T-score	0.009	0.004	0.011*	0.009	0.004	0.022*
FRAX MOF	−0.013	0.007	0.090	−0.001	0.006	0.907
FRAX HF	−0.008	0.005	0.117	−0.001	0.004	0.887
All (n = 251)‡
Lumbar 2–4 (L2-4) T-score	0.001	0.000	<0.001*	0.001	0.000	<0.001*
Femoral neck T-score	0.001	0.000	<0.001*	0.001	0.000	<0.001*
Total hip T-score	0.001	0.000	0.001	0.001	0.000	<0.001*
Minimum T-score	0.009	0.001	<0.001*	0.008	0.001	<0.001*
FRAX MOF	−0.017	0.002	<0.001*	−0.011	0.002	<0.001*
FRAX HF	−0.016	0.002	<0.001*	−0.004	0.002	0.006

Notes: *p<0.05, ^†Multivariable linear regression was adjusted for age, smoking habit, alcohol consumption.

Abbreviations: BMI, diabetes duration, FBG, HbA1c, diabetes medical treatment, total cholesterol, triglycerides, HDL-C, LDL-C, creatinine, and uric acid. ^‡Multivariable linear regression was adjusted for sex, age, smoking habit, alcohol consumption, BMI, diabetes duration, FBG, HbA1c, diabetes medical treatment, total cholesterol, triglycerides, HDL-C, LDL-C, creatinine, and uric acid; BMD, bone mineral density; CI, confidence interval; FRAX, fracture risk algorithm; MOF, major osteoporotic fractures; HF, hip fractures; SE, standard error.