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. 2023 Feb 3;14:1089905. doi: 10.3389/fimmu.2023.1089905

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Copyright © 2023 Suzuki, Kami, Taya, Sano, Ogata, Matoba and Gojo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Western blotting analysis of the molecular pathways of peritoneal cavity cells at 24 hours post-CLP. The graph shows the expression ratio of each protein corrected by Gapdh protein expression level (n = 3). (B) The assessment of lysosomal acidification in THP-1 cells at 5 days post-Wortmannin administration. The statistical significance of differences among two groups, with or without ZLN005 in Wortmannin administration, were evaluated using Kolmogorov-Smirnov test. P values ** < 0.0001, P values * 0.0001 to 0.05.