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. 2023 Feb 18;14:931. doi: 10.1038/s41467-023-36593-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Distribution of various compositions of PLN protomers within GJICh particles. Three datasets of Cx43 in detergents and nanodiscs were analyzed. For each dataset, the highest percentage is indicated by an asterisk. b Distribution of various compositions of GCN (left), FIN (middle), and PLN (right) protomers in each half of the GJICh particles for Cx43-M257 in POPE nanodiscs (condition 8). c Schematic drawings for the possible arrangements of PLN protomers in hemichannels for the three datasets shown in (a). Orange and gray circles represent PLN protomers and the others (GCN or FIN), respectively. For all arrangements, the predicted probability and experimental values from the three datasets are indicated. d Interfaces between protomers for Cx43-M257 heteromeric GJICh composed of PLN (orange) and GCN (green) protomers. Residues at the interfaces between the protomers were drawn as sticks. e Interfaces between protomers for Cx43-M257 heteromeric GJICh composed of PLN (orange) and FIN (red) protomers.