Table 4.
Summary of functional, molecular, and structural differences between FS-R and FS-V animals in PFC synaptosomes, gliosomes, and whole tissue.
| PFC SYNAPTOSOMES | FS-R | FS-V |
|---|---|---|
| Basal glutamate release | = | ↑ |
| Depolarization-evoked glutamate release | ↑ | ↑ |
| pSer9-synapsin I protein levels (synaptic membranes) | ↑ | ↑ |
| GluN2A protein levels and GluN2A/GluN2B ratio (synaptic membranes) | ↓ | ↓ |
| PFC GLIOSOMES | ||
|---|---|---|
| Basal glutamate release | = | = |
| Depolarization-evoked glutamate release | = | ↑ |
| GLT1 protein levels | ↑ | = |
| GS protein levels | ↓ | = |
| XCt protein levels | ↑ | = |
| TOTAL PFC | ||
|---|---|---|
| Dendritic length and branching (prelimbic PFC layers II–III pyramidal neurons) | ↓ | ↓ |
| BDNF mRNA levels | = | ↓ |
| GDNF mRNA levels | = | = |
Arrows/equals represent the comparison vs control animals.
The parameters which were found different between FS-R and FS-V rats are highlighted in bold.