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. 2023 Feb 18;22:15. doi: 10.1186/s12938-023-01078-y

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Histological sections and histomorphometrical analysis of calvarial bone defects. A Representative images of H&E and Masson’s trichrome stains at 4 and 8 weeks. B Percentage of new bone formed area in H&E stains (blue bar), and C red-stained area in Masson’s trichrome stains at 4 and 8 weeks. Scale bar = 1 mm (×20 images), 200 µm (×100 images), and 50 µm (×400 images in the dotted line box). Fb: fibrous tissues; NB: newly formed bone; HB: host bone; M: implanted beads; asterisk: blood vessel. p < 0.05 compared to the blank (*), HAp (†), Qct (‡), and BMP-2 (§) groups