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Permeability Measured with PAMPA for Selected Compoundsa
| Compound | 7 | 8 | 9 | 11 | 12 | 13 | 14 |
|---|---|---|---|---|---|---|---|
|
Permeability
(x 10−6 cm/s) |
0.015 | 0.09 | 0.000 | 0.488 | 1.15 | 0.24 | 0.971 |
| TPSA (Å2) | 192.6 | 181.6 | 155.3 | 201.8 | 201.8 | 170.7 | 170.7 |
Experiments were performed in duplicate for each compound. Controls: theophylline (low control) 0.27-0.33 x 10−6 cm/s, diclofenac (medium control) 2.91-3.13 x 10−6 cm/s, and chloramphenicol (high control) 4.36-4.99 x 10−6 cm/s.
