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. 2023 Feb 16;11:e14824. doi: 10.7717/peerj.14824

Figure 1. Intron splicing of KRT4 pre-mRNA is suppressed in OSCC.

Figure 1

(A) Schematic diagram of KRT4 pre-mRNA. (B) Fragments of KRT4 pre-mRNA containing exon-intron structures or KRT4 mRNA detected by PCR in NOK cells and HN6 cells. Red arrows indicated fragments of KRT4 pre-mRNA containing exon-intron structures. (C) Levels of junctions of exon 2-exon 3 (E2/E3), exon 3-exon 4 (E3/E4) and exon 5-exon 6 (E5/E6) in KRT4 mRNA detected by qRT-PCR in NOK cells and HN6 cells. E, exon. ∗∗∗P < 0.001, ∗∗∗∗P < 0.0001.