TABLE 4.
Adverse events
| Any grade | G3‐4 | G1‐2 | |
|---|---|---|---|
| Hypertension | 54 (44.6) | 5 (4.1) | 49 (40.5) |
| Thrombocytopenia | 45 (37.2) | 4 (3.3) | 41 (33.9) |
| Fatigue | 44 (36.4) | 0 | 44 (36.4) |
| AST elevation | 42 (34.7) | 9 (7.4) | 33 (27.3) |
| Proteinuria | 35 (28.9) | 5 (4.1) | 30 (24.7) |
| Anemia | 30 (24.8) | 1 (0.8) | 29 (24.0) |
| ALT elevation | 24 (19.8) | 3 (2.5) | 21 (17.4) |
| Blood bilirubin increase | 24 (19.8) | 2 (1.6) | 22 (18.2) |
| Nausea | 24 (19.8) | 1 (0.8) | 23 (19.0) |
| Anorexia | 23 (19.0) | 0 | 23 (19.0) |
| Neutropenia | 14 (11.6) | 3 (2.5) | 11 (9.1) |
| Rash | 13 (10.7) | 2 (1.7) | 11 (9.1) |
| Pruritus | 13 (10.7) | 3 (0.8) | 10 (8.2) |
| Gastrointestinal bleeding | 6 (5.0) | 4 (3.3) | 2 (1.7) |
| Vomiting | 6 (5.0) | 0 | 6 (5.0) |
| Diarrhea | 6 (5.0) | 0 | 6 (5.0) |
| Gastrointestinal perforation | 3 (2.5) | 3 (2.5) | 0 |
| Hypothyroidism | 1 (0.8) | 0 | 1 (0.8) |
| Intracranial hemorrhage | 1 (0.8) | 1 (0.8) | 0 |
| Pulmonary embolism | 1 (0.8) | 1 (0.8) | 0 |
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase.