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. 2022 Jul 26;12(3):3758–3772. doi: 10.1002/cam4.5071

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© 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Knockdown of core genes inhibits cell proliferation demonstrated through MTT assay, colony formation assay, EdU assay. (A) Down expression of GADPH inhibits MDA‐MB‐231 cell growth. (B) Down expression of CDH2 inhibits T47D cell growth. (C) Down expression of BIRC5 inhibits MDA‐MB‐231 cell growth. (D) Down expression of NEK2 inhibits MCF‐7 cell growth. (E) Down expression of IDH2 inhibits SK‐BR‐3 cells growth. (F) Down expression of MELK inhibits MDA‐MB‐231 cell growth. The data were shown as mean ± SD obtained from at least three independent experiments. The statistical significance (**, p < 0.01; ***, p < 0.001) is determined through Student's t‐test. (a) MTT assay, (b) colony formation assay, (c) EdU assay.