TABLE 1.
Baseline characteristics of dMMR patients with (N = 31) or without NCT (N = 335).
| Total (N = 335) | Yes (N = 31) | No (N = 304) | p value | |
|---|---|---|---|---|
| Age | 0.671 | |||
| Mean (SD) | 54.7 (13.2) | 55.7 (10.9) | 54.7 (13.4) | |
| Median [Min, Max] | 55.0 [19.0, 83.0] | 57.0 [35.0, 75.0] | 54.0 [19.0, 83.0] | |
| Sex | 0.314 | |||
| Male | 193 (57.6%) | 21 (67.7%) | 172 (56.6%) | |
| Female | 142 (42.4%) | 10 (32.3%) | 132 (43.4%) | |
| CEA | <0.001 | |||
| Abnormal | 69 (20.6%) | 16 (51.6%) | 53 (17.4%) | |
| Normal | 197 (58.8%) | 12 (38.7%) | 185 (60.9%) | |
| Missing | 69 (20.6%) | 3 (9.7%) | 66 (21.7%) | |
| CA19.9 | 0.197 | |||
| Abnormal | 40 (11.9%) | 7 (22.6%) | 33 (10.9%) | |
| Normal | 227 (67.8%) | 21 (67.7%) | 206 (67.8%) | |
| Missing | 68 (20.3%) | 3 (9.7%) | 65 (21.4%) | |
| Laparoscope | 0.090 | |||
| Laparotomy | 111 (33.1%) | 15 (48.4%) | 96 (31.6%) | |
| Laparoscope | 224 (66.9%) | 16 (51.6%) | 208 (68.4%) | |
| Multiorgan resection | 0.006 | |||
| Yes | 63 (18.8%) | 12 (38.7%) | 51 (16.8%) | |
| No | 272 (81.2%) | 19 (61.3%) | 253 (83.2%) | |
| Diameter | 0.033 | |||
| Mean (SD) | 6.30 (2.64) | 7.26 (3.39) | 6.21 (2.54) | |
| Median [Min, Max] | 6.00 [1.50, 18.0] | 7.00 [2.50, 18.0] | 6.00 [1.50, 15.0] | |
| Subtype | 0.096 | |||
| Swell | 172 (51.3%) | 11 (35.5%) | 161 (53.0%) | |
| Ulceration+Infiltration | 163 (48.7%) | 20 (64.5%) | 143 (47.0%) | |
| Histology | 0.085 a | |||
| Aden | 296 (88.4%) | 25 (80.6%) | 271 (89.1%) | |
| Muci | 26 (7.8%) | 6 (19.4%) | 20 (6.6%) | |
| Sign | 1 (0.3%) | 0 (0%) | 1 (0.3%) | |
| Mixed | 12 (3.6%) | 0 (0%) | 12 (3.9%) | |
| Differentiation | 0.133 a | |||
| Well | 14 (4.2%) | 3 (9.7%) | 11 (3.6%) | |
| Moderate | 185 (55.2%) | 14 (45.2%) | 171 (56.3%) | |
| Poor | 128 (38.2%) | 14 (45.2%) | 114 (37.5%) | |
| Missing | 8 (2.4%) | 0 (0%) | 8 (2.6%) | |
| Lymphovascular invasion | 0.908 | |||
| Yes | 62 (18.5%) | 5 (16.1%) | 57 (18.8%) | |
| No | 273 (81.5%) | 26 (83.9%) | 247 (81.3%) | |
| Nerve invasion | 1.000 a | |||
| Yes | 38 (11.3%) | 3 (9.7%) | 35 (11.5%) | |
| No | 297 (88.7%) | 28 (90.3%) | 269 (88.5%) | |
| Tumor deposit | 1.000 a | |||
| Yes | 12 (3.6%) | 1 (3.2%) | 11 (3.6%) | |
| No | 323 (96.4%) | 30 (96.8%) | 293 (96.4%) | |
| Local invasion | 0.152 a | |||
| Yes | 15 (4.5%) | 3 (9.7%) | 12 (3.9%) | |
| No | 320 (95.5%) | 28 (90.3%) | 292 (96.1%) | |
| TLN | 0.091 | |||
| Mean (SD) | 34.6 (16.5) | 39.4 (23.1) | 34.1 (15.7) | |
| Median [Min, Max] | 31.0 [7.00, 104] | 32.0 [13.0, 97.0] | 31.0 [7.00, 104] | |
| NLN | 0.065 | |||
| Mean (SD) | 33.8 (16.8) | 39.1 (23.0) | 33.2 (16.0) | |
| Median [Min, Max] | 30.0 [6.00, 104] | 31.0 [13.0, 97.0] | 30.0 [6.00, 104] | |
| PLN | 0.256 | |||
| Mean (SD) | 0.863 (2.61) | 0.355 (0.839) | 0.914 (2.72) | |
| Median [Min, Max] | 0 [0, 24.0] | 0 [0, 4.00] | 0 [0, 24.0] | |
| pT | 0.409 a | |||
| T1–T3 | 216 (64.5%) | 17 (54.8%) | 199 (65.5%) | |
| T4 | 119 (35.5%) | 14 (45.2%) | 105 (34.5%) | |
| pN | 0.648 a | |||
| N0 | 246 (73.4%) | 23 (74.2%) | 223 (73.4%) | |
| N1 | 64 (19.1%) | 7 (22.6%) | 57 (18.8%) | |
| N2 | 25 (7.5%) | 1 (3.2%) | 24 (7.9%) | |
| PTNM | 0.286 a | |||
| I | 24 (7.2%) | 0 (0%) | 24 (7.9%) | |
| II | 222 (66.3%) | 23 (74.2%) | 199 (65.5%) | |
| III | 89 (26.6%) | 8 (25.8%) | 81 (26.6%) | |
| Adjuvant chemotherapy | <0.001 | |||
| Yes | 180 (53.7%) | 27 (87.1%) | 153 (50.3%) | |
| No | 150 (44.8%) | 4 (12.9%) | 146 (48.0%) | |
| Missing | 5 (1.5%) | 0 (0%) | 5 (1.6%) |
Abbreviations: Aden, adenocarcinoma; Muci, mucinous adenocarcinoma; Sign, signet‐ring cell carcinoma; Mixed, could not be classified.
a
Fisher's exact test.