TABLE 2.
Univariate and multivariate Cox regression analysis for DFS in dMMR patients.
| Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |
| Age | 1.01 | 0.97–1.05 | 0.589 | |||
| Sex | ||||||
| Male versus Female | 1.60 | 0.56–4.61 | 0.383 | |||
| CEA | ||||||
| Abnormal versus Normal a | 2.47 | 0.83–7.35 | 0.104 | |||
| CA19‐9 | ||||||
| Abnormal versus Normal b , d | 5.09 | 1.71–15.13 | 0.003 | |||
| Laparoscope | ||||||
| Laparoscope versus Laparotomy | 0.39 | 0.14–1.03 | 0.058 | |||
| Tumor size | 1.00 | 0.84–1.21 | 0.963 | |||
| NACT | ||||||
| Yes versus No | 2.26 | 0.64–7.92 | 0.204 | 3.15 | 0.81–12.15 | 0.096 |
| Multi‐organ resection | ||||||
| Yes versus No | 4.50 | 1.69–11.99 | 0.003 | |||
| Subtype | ||||||
| Ulceration+Infiltration versus Swell | 2.32 | 0.81–6.68 | 0.119 | |||
| Histology | ||||||
| Adenocarcinoma versus other c | 0.57 | 0.16–2.00 | 0.378 | |||
| Lymphovascular invasion | ||||||
| Yes versus No | 3.69 | 1.37–9.90 | 0.010 | |||
| Nerve invasion | ||||||
| Yes versus No | 3.94 | 1.37–11.34 | 0.011 | 2.42 | 0.81–7.28 | 0.116 |
| Tumor deposit | ||||||
| Yes versus No | 10.27 | 3.31–31.88 | <0.001 | 6.73 | 2.08–21.74 | 0.001 |
| Local invasion | ||||||
| Yes versus No | 8.36 | 2.69–25.95 | <0.001 | |||
| pT | ||||||
| pT4 versus pT1‐3 | 13.27 | 3.02–58.42 | <0.001 | 14.97 | 1.88–118.92 | 0.010 |
| TLN | 0.99 | 0.96–1.02 | 0.493 | |||
| NLN | 0.97 | 0.93–1.01 | 0.967 | |||
| PLN | 1.18 | 1.11–1.26 | <0.001 | 1.17 | 1.09–1.26 | <0.001 |
| Adjuvant chemotherapy | ||||||
| Yes versus No | 11.94 | 1.57–90.82 | 0.017 | |||
a
Normal: CEA ≤ 5 ng/ml; abnormal: CEA > 5 ng/ml.
b
Normal: CA19‐9 ≤ 37 U/ml; abnormal: CA19‐9 > 37 U/ml.
c
“Other” includes mucinous adenocarcinoma, signet‐ring cell carcinoma and mixed type which could not be classified.
d
CA19‐9 did not involve in multivariate COX regression analysis because a large proportion of patients did not test CA19‐9 before NCT or surgery.