TABLE 3.
Baseline characteristics of dMMR (N = 31) and pMMR (N = 21) colon cancer patients with NCT.
| Total (N = 52) | dMMR (N = 31) | pMMR (N = 21) | p value | |
|---|---|---|---|---|
| Age | 0.627 | |||
| Mean (SD) | 55.1 (11.3) | 55.7 (10.9) | 54.1 (12.0) | |
| Median [Min, Max] | 57.0 [29.0, 75.0] | 57.0 [35.0, 75.0] | 57.0 [29.0, 74.0] | |
| Sex | 0.627 | |||
| Male | 33 (63.5%) | 21 (67.7%) | 12 (57.1%) | |
| Female | 19 (36.5%) | 10 (32.3%) | 9 (42.9%) | |
| CEA | 0.718 | |||
| Abnormal | 25 (48.1%) | 16 (51.6%) | 9 (42.9%) | |
| Normal | 22 (42.3%) | 12 (38.7%) | 10 (47.6%) | |
| CA19.9 | 0.194 | |||
| Abnormal | 8 (15.4%) | 7 (22.6%) | 1 (4.8%) | |
| Normal | 38 (73.1%) | 21 (67.7%) | 17 (81.0%) | |
| cT | * | |||
| cT3 | 0 (0%) | 0 (0%) | 0 (0%) | |
| cT4 | 52 (100%) | 31 (100%) | 21 (100%) | |
| cN | 0.264 a | |||
| cN0 | 3 (5.8%) | 3 (9.7%) | 0 (0%) | |
| cN+ | 49 (94.2%) | 28 (90.3%) | 21 (100%) | |
| cTNM | 0.264 a | |||
| II | 3 (5.8%) | 3 (9.7%) | 0 (0%) | |
| III | 49 (94.2%) | 28 (90.3%) | 21 (100%) | |
| Laparoscope | 0.309 | |||
| Laparotomy | 29 (55.8%) | 15 (48.4%) | 14 (66.7%) | |
| Laparoscope | 23 (44.2%) | 16 (51.6%) | 7 (33.3%) | |
| Diameter | 0.001 | |||
| Mean (SD) | 6.08 (3.17) | 7.26 (3.39) | 4.32 (1.73) | |
| Median [Min, Max] | 5.65 [1.50, 18.0] | 7.00 [2.50, 18.0] | 4.00 [1.50, 8.50] | |
| Subtype | 1.000 | |||
| Swell | 18 (34.6%) | 11 (35.5%) | 7 (33.3%) | |
| Ulceration + Infiltration | 34 (65.4%) | 20 (64.5%) | 14 (66.7%) | |
| Histology | 0.070 a | |||
| Aden | 46 (88.5%) | 25 (80.6%) | 21 (100%) | |
| Muci | 6 (11.5%) | 6 (19.4%) | 0 (0%) | |
| Sign | 0 (0%) | 0 (0%) | 0 (0%) | |
| Mixed | 0 (0%) | 0 (0%) | 0 (0%) | |
| Differentiation | 0.024 a | |||
| Well | 6 (11.5%) | 3 (9.7%) | 3 (14.3%) | |
| Moderate | 29 (55.8%) | 14 (45.2%) | 15 (71.4%) | |
| Poor | 16 (30.8%) | 14 (45.2%) | 2 (9.5%) | |
| Lymphovascular invasion | 0.414 | |||
| Yes | 6 (11.5%) | 5 (16.1%) | 1 (4.8%) | |
| No | 46 (88.5%) | 26 (83.9%) | 20 (95.2%) | |
| Nerve invasion | 0.388 | |||
| Yes | 3 (5.8%) | 3 (9.7%) | 0 (0%) | |
| No | 49 (94.2%) | 28 (90.3%) | 21 (100%) | |
| Tumor deposit | 1.000 | |||
| Yes | 2 (3.8%) | 1 (3.2%) | 1 (4.8%) | |
| No | 50 (96.2%) | 30 (96.8%) | 20 (95.2%) | |
| Local invasion | 0.577 | |||
| Yes | 7 (13.5%) | 3 (9.7%) | 4 (19.0%) | |
| No | 45 (86.5%) | 28 (90.3%) | 17 (81.0%) | |
| TLN | 0.026 | |||
| Mean (SD) | 34.3 (20.5) | 39.4 (23.1) | 26.6 (13.1) | |
| Median [Min, Max] | 26.0 [9.00, 97.0] | 32.0 [13.0, 97.0] | 24.0 [9.00, 66.0] | |
| NLN | 0.017 | |||
| Mean (SD) | 33.5 (20.7) | 39.1 (23.0) | 25.3 (13.2) | |
| Median [Min, Max] | 25.5 [8.00, 97.0] | 31.0 [13.0, 97.0] | 21.0 [8.00, 66.0] | |
| PLN | 0.015 | |||
| Mean (SD) | 0.750 (1.44) | 0.360 (0.839) | 1.33 (1.91) | |
| Median [Min, Max] | 0 [0, 7.00] | 0 [0, 4.00] | 0 [0, 7.00] | |
| pT | 0.212 a | |||
| T1 | 0 (0%) | 0 (0%) | 0 (0%) | |
| T2 | 2 (3.8%) | 0 (0%) | 2 (9.5%) | |
| T3 | 29 (55.8%) | 17 (54.8%) | 12 (57.1%) | |
| T4 | 21 (40.4%) | 14 (45.2%) | 7 (33.3%) | |
| pN | 0.106 a | |||
| N0 | 33 (63.5%) | 23 (74.2%) | 10 (47.6%) | |
| N1 | 15 (28.8%) | 7 (22.6%) | 8 (38.1%) | |
| N2 | 4 (7.7%) | 1 (3.2%) | 3 (14.3%) | |
| pTNM | 0.029 a | |||
| I | 1 (1.9%) | 0 (0%) | 1 (4.8%) | |
| II | 32 (61.5%) | 23 (74.2%) | 9 (42.9%) | |
| III | 19 (36.5%) | 8 (25.8%) | 11 (52.4%) | |
| Adjuvant chemotherapy | 0.138 | |||
| Yes | 48 (92.3%) | 27 (87.1%) | 21 (100%) | |
| No | 4 (7.7%) | 4 (12.9%) | 0 (0%) |
Abbreviations: Aden, adenocarcinoma; Mixed, could not be classified; Muci, mucinous adenocarcinoma; Sign, signet‐ring cell carcinoma.
a
Fisher's exact test.
*
Did not do analysis.