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. 2022 Aug 10;12(3):3786–3796. doi: 10.1002/cam4.5110

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© 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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ITGA5 and ITGB1 promoted Sorafenib resistance by enhancing hypoxia and VM formation. (A) Confirmation of ITGA5 or ITGB1 overexpression cells by Western blot. (B) Evaluation of tolerance to Sorafenib in control and ITGA5 or ITGB1 overexpressing cells by cell killing assay. (C) Detection of hypoxia level in control and ITGA5 or ITGB1 overexpressing cells by flow cytometry assay. (D) Quantification of VM structure in control and ITGA5 or ITGB1 overexpressing cells by PAS staining. Microphotographs were collected and uploaded into ImageJ software for quantification. ITGA5, integrins A5; ITGB1, integrins B1; PAS, periodic acid schiff; VM, vasculogenic mimicry. *: p〈0.05 ; **: p〈0.01; ***: p〈0.001.