TABLE 1.
Characteristics individuals with variant of uncertain significance (VUS) across three to four study sites (N = 2715)
| Variable | Category | Cooper | MD Anderson | OhioHealth | Baptist | Total |
|---|---|---|---|---|---|---|
| n = 515 (%) | n = 1685 (%) | n = 358 (%) | n = 157 (%) | N = 2715 (%) | ||
| Date of genetic counseling | 2013–2018 | 2013–2019 | 2014–2018 | 2014–2018 | 2013–2019 | |
| Sex | Female | 497 (96.50) | 1392 (82.61) | 337 (94.13) | 147 (93.63) | 2373 (87.40) |
| Male | 36 (6.99) | 293 (17.39) | 21 (5.87) | 10 (6.37) | 360 (13.26) | |
| Race/Ethnicity | NH Asian | 17 (3.30) | 138 (8.19) | 13 (3.63) | 3 (1.91) | 171 (6.30) |
| Hispanic or Latino | 44 (8.54) | 252 (14.96) | 4 (1.12) | 0 (0.00) | 300 (11.05) | |
| NH Black | 90 (17.48) | 206 (12.23) | 42 (11.73) | 31 (19.75) | 369 (13.59) | |
| NH White | 349 (67.77) | 1039 (61.66) | 291 (81.28) | 118 (75.16) | 1797 (66.19) | |
| Other | 11 (2.14) | 17 (1.01) | 2 (0.56) | 5 (3.18) | 35 (1.29) | |
| Unknown | 4 (0.78) | 33 (1.96) | 6 (1.68) | 0 (0.00) | 43 (1.58) | |
| Personal history of cancer | Breast | 270 (52.43) | 820 (48.66) | 260 (72.63) | 80 (50.96) | 1350 (49.72) |
| Ovarian | 15 (2.91) | 123 (7.30) | 24 (6.70) | 19 (12.1) | 162 (5.97) | |
| Colorectal | 9 (1.75) | 138 (8.19) | 21 (5.87) | 6 (3.82) | 168 (6.19) | |
| Other | 94 (18.25) | 525 (31.16) | 31 (8.66) | 8 (5.1) | 650 (23.94) | |
| Unaffected | 127 (24.66) | 79 (4.69) | 22 (6.15) | 44 (28.03) | 228 (8.40) | |
| Genetic testing year | 2002–2009 | 2 (0.39) | 12 (0.71) | 0 (0.00) | 0 (0.00) | 14 (0.52) |
| 2010–2012 | 0 (0.00) | 12 (0.71) | 0 (0.00) | 1 (0.64) | 13 (0.48) | |
| 2013–2015 | 93 (18.06) | 273 (16.20) | 44 (12.29) | 4 (2.55) | 414 (15.25) | |
| 2016–2018 | 401 (77.86) | 919 (54.54) | 304 (84.92) | 151 (96.18) | 1775 (65.38) | |
| 2019–2020 | 18 (3.50) | 464 (27.54) | 10 (2.79) | 1 (0.64) | 493 (18.16) | |
| Test result type | VUS only | 458 (88.93) | 1493 (88.61) | 320 (89.39) | 144 (91.72) | 2415 (88.95) |
| VUS + P/LP | 57 (11.07) | 192 (11.39) | 38 (10.61) | 13 (8.28) | 300 (11.05) | |
| Variant reclassification | 104 (20.19) | 81 (4.81) | 27 (7.54) | 14 (8.92) | 226 (8.32) | |