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Variant reclassifications by type
| No. Unique Variants (n = 3574) | |||
|---|---|---|---|
| P/LP | VUS | Total | |
| No. Initially detected | 313 | 3261 | 3574 |
| No. Reclassified (%) a | 7 (2.23) | 240 (7.36) | 247 (6.91) |
| Upgraded (%) | 5 (71.4) | 27 (11.3) | 32 (12.9) |
| Downgraded (%) | 2 (28.6) | 213 (88.7) | 215 (87.1) |
Some underwent both upgrade and downgrade; Variant reclassifications were defined as downgrades if the variant was reclassified from P/LP to VUS, P to LP, or from VUS to B/LB, and upgrades if the convserse happened.
