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. 2022 Aug 24;12(3):3260–3275. doi: 10.1002/cam4.5068

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© 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Dose effects of dimethylarsenic acid on cytochrome C release and Bcl‐2 family protein translocation in MA‐10 cells. Cells were challenged with dimethylarsenic acid (0, 0.1, 1 and 10 mM) for 12 and 24 h, respectively. Cytochrome C (14 kDa), Bid (22 kDa), and Bax (20 kDa) were respectively examined in mitochondrial (Mito) and cytosolic (Cyto) fractions via western blotting. Represent immunoblots are from one single experiment repeated at least 3 times (A). COX IV (17 kDa) and β‐Actin (43 kDa) were exploited as loading controls for cytosolic and mitochondrial fractions, correspondingly. IOD of cytochrome C (B), Bax (C), and Bid (D) was determined with loading control normalization for each lane. Results in B, C, and D illustrate the mean ± SEM of 3 independent experiments. The * represents statistical difference as compared to control group, respectively (p < 0.05).