TABLE 3.

Tumor burden changes from baseline to Week 12

	VC (tumor diameter)	LC (tumor diameter)	VC (tumor volume)	LC (tumor volume)
Number of evaluable patients	14	21	14	21
Mean change in tumor burden a	−40.03%	−21.19%	−64.15%	−25.59%
p value b	0.086		0.13

Abbreviations: LC, Lapatinib + Capecitabine; VC, Varlitinib + Capecitabine.

^a Tumor burden computed as per Response Evaluation Criteria in Solid Tumor, by summing the size of up to 5 target tumors independent of tumor location, considering not more than 2 tumors per location.

^b p value corresponding to statistical significance of inter‐arm difference in mean changes in tumor burden (Wilcoxon rank test).