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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Adv Drug Deliv Rev. 2022 May 23;187:114358. doi: 10.1016/j.addr.2022.114358

Fig 3. OFF, OR, AND Strategies with Adapter CAR T Cells.

Fig 3.

A) An inhibitory scFv works as an OFF switch in the SUPRA CAR design. B) SUPRA CAR T cells can target cytotoxicity to Her+ OR Axl+ tumor cells with different zipFvs. C) Co-LOCKR AND gate requires both antigen A and B on a tumor cell surface for functional CAR T cytotoxicity.