Fig. 2.

Possible oocyte spindle scaling models. A. Oocyte spindle is scaled by cytoplasmic size. B. Hypotheses of spindle scaling models. C. Spindle scaling by cytoplasmic size is explained with a nuclear factor scaling model. D. In the nuclear factor scaling model, oocytes halved after NEBD should form normal-sized spindles. However, small-sized spindles were formed. E. Spindle scaling by cytoplasmic size is explained with a distance from the cortex scaling model. F. In the distance from the cortex scaling model, dumbbell-shaped doubled oocytes should form normal-sized spindles. However, large-sized spindles were formed.