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. Author manuscript; available in PMC: 2024 Feb 1.
Published in final edited form as: ACS Chem Neurosci. 2023 Jan 11;14(3):351–358. doi: 10.1021/acschemneuro.2c00718

Figure 3. Intrinsic excitability is not impacted by a single administration of 5-MeO.

Figure 3.

(A) Layer 5 mPFC pyramidal neurons from animals administered a single dose of 5-MeO (10 mg/kg, IP) 24 h prior to tissue collection showed no significant difference in action potential firing rates in response to depolarizing current injection (n = 75 neurons, 6 animals per group) compared to neurons from animals that were given saline (n = 87 neurons, 6 animals per group). (B) Sample traces of neurons from animals treated with vehicle (black) and 5-MeO (red) in response to +200, +100, 0, −100, and −200 pA current injections (scale bars: 200 ms, 20 mV). (C) Resting membrane potential (RMP) was significantly more depolarized in animals treated with 5-MeO (p = 0.020), but all other intrinsic cellular properties were largely unchanged by the drug treatment. Data represent mean ± SEM. *p < 0.05, Student’s t-test.