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. 2022 May 25;13(1):157–173. doi: 10.1016/j.apsb.2022.05.019

Figure 8.

Figure 8

DCPR049_12 suppresses the lung cancer cell growth. (A) The cell proliferation was determined by cell number counting assay in lung cancer cells treated with DCPR049_12 (Data represent mean values ± SD from three independent experiments). (B) The colony formation was determined in lung cancer cells treated with DCPR049_12 (Data represent mean values ± SD from three independent experiments). (C) The cell proliferation was determined by cell number counting assay in BEAS-2B cells treated with DCPR049_12 (Data represent mean values ± SD from three independent experiments). (D) Tumor growth was compared between xenograft nude mice injected with H460 cells treated with DCPR049_12 (n = 7). (E) All tumors from nude mouse were shown. (F) Tumor mass of xenograft nude mice injected with H460 cells and treated with DCPR049_12 (n = 7). (G) Ki67, 6PGD, ENO1, and PRMT6 were analyzed in a representative DCPR049_12 treated H460 tumor by IHC. (H) The arginine methylation levels of 6PGD/ENO1 and 6PGD/ENO1 were analyzed by immunoprecipitation (IP) assay in a representative DCPR049_12 treated and control H460 cells tumor. (I) Tumor growth was compared between xenograft nude mice injected with H1299 cells and treated with DCPR049_12 (n = 6). (J) All tumors from nude mouse were shown. (K) Tumor mass in xenograft nude mice injected with H1299 cells and treated with DCPR049_12 (n = 6). (L) Ki67, 6PGD, ENO1, and PRMT6 were analyzed in a representative DCPR049_12 treated H1299 cell xenograft tumor by IHC. (M) The arginine methylation levels of 6PGD/ENO1 and 6PGD/ENO1 were analyzed by IP assay in are presentative DCPR049_12 treated and control H1299 cells tumor. ∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001.