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. 2022 Apr 11;13(1):372–389. doi: 10.1016/j.apsb.2022.04.002

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Fig. 5 — In vivo blood drug concentration and safety of NPs. (A) In vivo blood drug concentration at 1, 2, 4, 8, 24, 36, 48, 60 and 72 h, and the drug was extracted. Blood drug concentrations were measured. (B) The macro images of RBC in a test tube after centrifugation (left) and suspension (right) from the direct Coombs' test (Di) and indirect Coombs' test (Indi). (C) The micro images of RBC from the Di and Indi. Scale bars = 200 μm. (D–F) Effects of NPs on inflammatory factors including IL-1β, IL-6, and TNF-α. Data are presented as mean ± SD (n = 4). ∗∗P < 0.01, ∗∗∗P < 0.001 vs LPS group. NS, not significant.