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. 2022 Apr 11;13(1):372–389. doi: 10.1016/j.apsb.2022.04.002

Figure 6.

Fig. 6

NPs targeting atherosclerosis and MRI cross-sections in mice. (A) Fluorescence distribution in heart and aorta. (B) The quantity of fluorescence total signal in the heart, aorta, and blood. (C) Fluorescence distribution in thymus, liver, spleen, lung, and kidney. (D)The quantity of fluorescence total signal in organs. (E) Frozen sections of the aortic root. DHE stained for ROS. Scale bars = 200 μm. (F, G) The quantity of Cou-6 and DHE in the aortic root. (H) Typical images of MRI of the abdominal aorta from different groups. The red circle in the middle outlined the cross-section of the abdominal aorta. The black parts suggested blood vessels with excellent transparency, the white parts indicated blocked signals from plaques of fat. (I) Visceral fat in the liver (typical Section 1) and fat near the kidney (typical Section 2). (J) Quantity of plaques in the abdominal aorta. (K) The amount of visceral fat in the liver and the amount of fat near the kidney. Data are presented as mean ± SD (n = 4). ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001. NS, not significant.