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Allosteric functional properties of pyrazol-4-yl-pyridine 8–13 at the hM4. (A) ACh-mediated [35S]-GTPγS accumulation binding curves in absence or presence of increasing concentrations of pyrazol-4-yl-pyridine compounds. (B) Efficacy cooperativity parameters and (C) efficacy parameters of pyrazol-4-yl-pyridine compounds obtained using the operational model of allosterism [Eq. (2)]. Values represent the mean ± SEM obtained from three experiments conducted in duplicate (total n = 6).
