Figure 3.

Biological processes in the livers from WT and cKO mice fed with HFD. (A) Overview of the single-cell RNA-seq. (B) t-SNE visualization of hepatic cell types. (C) Violin plots show representative marker gene expression for each cell type. (D) Bubble plots show significantly changed KEGG pathways in macrophages. (E) Bubble plots show significantly changed GO analysis in hepatocytes. 17β-HSD7, 17β-hydroxysteroid dehydrogenase type 7; GO, gene ontology; HFD, high-fat diet; KEGG, Kyoto Encyclopedia of Genes and Genomes; t-SNE, T-distributed Stochastic Neighbor Embedding.