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. 2023 Jan 5;3(1):100382. doi: 10.1016/j.crmeth.2022.100382

Figure 5.

Figure 5

Discovery of cell-type-specific molecular networks and significant ligand-receptor interactions in Alzheimer’s disease (AD) using autoCell

(A) UMAP visualization of subclusters of astrocytes (including disease-associated astrocyte [DAA]), microglia, and OPCs, labeled with autoCell clusters.

(B) Reconstruction of the DAA-specific molecular subnetwork from the human protein-protein interactome. The DAA-specific module network included 50 protein-protein interactions (PPIs) connected by 44 proteins (e.g., APOE, MAPT, CD44, FOS, and STAT3). The proteins from the DAA-specific molecular network are enriched with multiple AD-related pathways, including cytokine signaling pathways. The proteins from the DAA-specific molecular network are enriched with multiple cytokine signaling pathways.

(C) Inferred cell-cell interactions using CellChat.

(D) Top selected significant ligand-receptor pairs among autoCell-identified cell types. Ligand-receptor interactions were predicted by CellChat (see STAR Methods).