Figure 3.

Sparse GMM module network

Left: a sample module network obtained through community detection algorithm to cancer and normal liver modules after running SparseGMM with different initializations. Right: the community detection clusters robust modules together into distinct subnetworks. Subnetworks at the periphery represent robust modules. Subnetworks are then functionally annotated using gene set enrichments analysis applied to MSigDB gene sets. Highlighted here are robust modules from normal liver and liver cancer, as well as shared communities that contain modules occurring in normal and cancer tissue.