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Incidence of pulmonary disorders and cardiovascular toxicity reported in dasatinib treatment.
| Pulmonary and cardiovascular toxicities | Patients (%) | |||
|---|---|---|---|---|
| First-line | Second-line | |||
| Dasatinib 100mg daily | Dasatinib 100mg daily | |||
| Any Grade | Grade 3/4 | Any Grade | Grade 3/4 | |
| Pulmonary disorders | ||||
| Pleural effusions | 10-35 | 0-9 | 9-26 | 2-8 |
| Pulmonary arterial hypertension | 2.6-5 | <1 | 2.4 | 1.1 |
| Cardiovascular Toxicity | ||||
| QTc prolongation | 1.6-73 | NR | NR | NR |
| Arterial vascular events | 5 | <1 | 4 | <1 |
NR, not reported.
