TABLE 1.
List of upregulated metabolites (red box in Figure 3C) in mouse brain samples in the (A) middle cerebral artery occlusion/reperfusion (MCAO/R) versus MCAO group and (B) MCAO/R versus sham group. VIP, variable importance in the projection. ***p < 0.001, **p < 0.01, *p < 0.05.
| (A) | |||||||
| No. | Peak | PubChem CID | VIP | p-value | Fold change | LOG2-FOLD change | Symbol |
| 1 | Glucose-6-phosphate 1 | 439958 | 2.864225757 | 0.000804747 | 50.74652331 | 5.66523708 | *** |
| 2 | Fructose-6-phosphate | 69507 | 2.765175119 | 0.000806093 | 46.90199453 | 5.55157737 | *** |
| 3 | Cellobiose 2 | 294 | 2.804271305 | 0.000987392 | 19.73237667 | 4.302492827 | *** |
| 4 | O-phosphonothreonine 1 | 3246323 | 2.721198038 | 1.00348E-05 | 14.21486503 | 3.829328495 | *** |
| 5 | Salicin | 439503 | 2.548609014 | 0.008142101 | 7.884287086 | 2.978980309 | ** |
| 6 | N-methyl-dl-alanine | 4377 | 2.676090698 | 0.002328932 | 6.995360732 | 2.806398455 | ** |
| 7 | Fructose 1 | 2723872 | 2.599885584 | 7.17725E-05 | 3.894194913 | 1.961325096 | *** |
| 8 | Alpha-aminoadipic acid | 469 | 2.365301057 | 0.002195341 | 3.171746923 | 1.665277662 | ** |
| 9 | 2-deoxy-d-galactose 2 | 439804 | 2.845734446 | 6.11E-08 | 2.276842157 | 1.187034279 | *** |
| 10 | 2-hydroxyvaleric acid | 98009 | 2.671278079 | 4.87E-06 | 1.957959376 | 0.969350832 | *** |
| 11 | N-acetylhistidine | 75619 | 0.438649611 | 0.271502312 | 1.683982608 | 0.751877239 | |
| 12 | Pentanenitrile | 8061 | 0.883952465 | 0.245370607 | 1.475431114 | 0.561136565 | |
| 13 | Histamine | 774 | 0.835540146 | 0.171526856 | 1.453719767 | 0.539749189 | |
| 14 | Trans-hexadec-2-enoyl carnitine | 53477817 | 1.586571196 | 0.055386681 | 1.452087929 | 0.538128816 | |
| 15 | 4-(diaminomethylideneamino)butanoic acid | 500 | 1.203379571 | 0.115068444 | 1.316114929 | 0.396285477 | |
| 16 | (2s)-pyrrolidine-2-carboxylic acid | 145742 | 1.003407193 | 0.217092683 | 1.230730605 | 0.299515005 | |
| 17 | 2,4-dioxo-1h-pyrimidine-6-carboxylic acid | 967 | 0.92441045 | 0.181361639 | 1.172030427 | 0.229010024 | |
| (B) | |||||||
| No. | Peak | PubChem CID | VIP | p-value | Fold change | LOG2-FOLD change | Symbol |
| 1 | N-Acetylhistidine | 75619 | 1.425608156 | 0.043606643 | 4.546159384 | 2.184648265 | * |
| 2 | Cellobiose 2 | 294 | 1.567909166 | 0.006986065 | 3.227477798 | 1.690407171 | ** |
| 3 | N-methyl-dl-alanine | 4377 | 1.560412669 | 0.008813379 | 3.186375681 | 1.671916374 | ** |
| 4 | Histamine | 774 | 1.793338316 | 0.01072478 | 2.66211923 | 1.412575188 | * |
| 5 | Pentanenitrile | 8061 | 1.601302512 | 0.029806448 | 2.618295492 | 1.388627924 | * |
| 6 | Salicin | 439503 | 1.587012182 | 0.044418362 | 2.549591691 | 1.350266222 | * |
| 7 | Glucose-6-phosphate 1/D-Glucose 6-Phosphate | 439958 | 1.349921938 | 0.020958135 | 2.447203193 | 1.291133894 | * |
| 8 | Fructose 1/D-Fructose | 2723872 | 1.8930859 | 0.000899086 | 2.196254683 | 1.135045363 | *** |
| 9 | Trans-hexadec-2-enoyl carnitine | 53477817 | 1.833941894 | 0.003975182 | 2.108838044 | 1.076448302 | ** |
| 10 | Fructose-6-phosphate | 69507 | 1.2351927 | 0.048094572 | 2.079969744 | 1.056562542 | * |
| 11 | O-phosphonothreonine 1 | 3246323 | 1.19286643 | 0.013213685 | 1.943043504 | 0.958318203 | * |
| 12 | Alpha-aminoadipic acid | 469 | 1.245659705 | 0.01876246 | 1.888682345 | 0.917380077 | * |
| 13 | 4-(diaminomethylideneamino) butanoic acid | 500 | 1.937622772 | 0.004980972 | 1.871241168 | 0.903995507 | ** |
| 14 | (2s)-pyrrolidine-2-carboxylic acid | 145742 | 1.543836617 | 0.011032748 | 1.658322057 | 0.729724215 | * |
| 15 | 2-hydroxyvaleric acid | 98009 | 1.879766387 | 4.33983E-05 | 1.57365224 | 0.654116756 | *** |
| 16 | 2,4-dioxo-1H-pyrimidine-6-carboxylic acid | 967 | 1.540557642 | 0.005099663 | 1.465252377 | 0.551149178 | ** |
| 17 | 2-deoxy-d-galactose 2 | 439804 | 1.573420229 | 0.003235868 | 1.326628475 | 0.407764397 | ** |