Table 1.
Effects of Lugol and 9-Phenanthrol on mechanically induced ectopics and basal heart properties
The left ventricle (LV) of isolated Langendorff perfused rat hearts were irrigated with Tyrode followed by irrigation with either Lugol (120 mM KI, 38.6 mM I2), 50 μM 9-Phenanthrol or Tyrode's. The LV was stretched pre and post intervention and the total number of ectopic activations and period of ectopics were measured. Lugol decreased both parameters, 9-Phen decreased ectopic number and Tyrode's increased ectopic period. Interventions had no significant effect on the heart rate or the increase in left ventricular developed pressure (Stretch LVDP) when balloon volume was increased from 50 μL to 150 μL. Data are mean ± SEM from 16 stretches for ectopics and 13–16 for LVDP, *p < 0.05. paired t-test Tyrode's vs Intervention.
| N (hearts) | Lugol |
9-Phen |
Tyrode |
|
|---|---|---|---|---|
| 8 | 8 | 8 | ||
| Number of ectopics | Tyrode | 15.31 ± 2.32 | 11.27 ± 1.78 | 12.25 ± 1.41 |
| Intervention | 1.0 ± 0.44 * | 6.87 ± 2.11 * | 9.94 ± 1.36 | |
| Period of ectopics (s) | Tyrode | 5.02 ± 0.75 | 3.79 ± 0.74 | 4.21 ± 0.36 |
| Intervention | 0.93 ± 0.47 * | 2.94 ± 1.07 | 7.90 ± 1.38 * | |
| Heart rate (bpm) | Tyrode | 192 ± 8 | 207 ± 18 | 195 ± 12 |
| Intervention | 209 ± 13 | 196 ± 13 | 180 ± 9 | |
| Stretch LVDP (mmHg) | Tyrode | 48.5 ± 6.6 | 23.5 ± 3.9 | 24.8 ± 3.0 |
| Intervention | 54.8 ± 7.1 | 27.7 ± 5.0 | 31.4 ± 4.6 | |