Table 2.
Antimicrobial activity of the ligand PhAlaSal and complexes in the Co(II)–PhAlaSal system, prepared directly and stored for two weeks, shown as minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) or minimal fungicidal concentration (MFC). Antibiotics: gentamicin, amoxicillin and amphotericin used as antibacterial and antifungal reference substances; (-) not tested.
| Microorganism | MIC/MBC/MFC (mM) |
MIC = MBC/MFC (mM) |
|||||
|---|---|---|---|---|---|---|---|
| Co (II)–PhAlaSal complexes |
PhAlaSal |
Gentamicin |
Amphotericin B |
Amoxicillin |
|||
| MIC | MBC | MIC | MBC | ||||
| Gram-negative bacteria | |||||||
| Pseudomonas aeruginosa ATCC 27853 | > 1.82 | > 1.82 | 7.30 | > 7.30 | < 0.008 | - | - |
| Escherichia coli ATCC 25922 | > 1.82 | > 1.82 | 7.30 | > 7.30 | < 0.004 | - | - |
| Helicobacter pylori CCUC 17874 | 1.82 | 1.82 | 3.65 | > 7.30 | - | - | < 0.001 |
| Helicobacter pylori ATCC 700392 | 1.82 | 1.82 | 3.65 | > 7.30 | - | - | < 0.001 |
| Gram-positive bacteria | |||||||
| Enterococcus faecalis ATCC 29212 | > 1.82 | > 1.82 | 7.30 | > 7.30 | < 0.26 | - | - |
| Staphylococcus aureus ATCC 29213 | > 1.82 | > 1.82 | 3.65 | > 7.30 | < 0.002 | - | - |
| Staphylococcus aureus ATCC 6538 | > 1.82 | > 1.82 | 3.65 | > 7.30 | < 0.002 | - | - |
| Staphylococcus epidermidis ATCC 12228 | > 1.82 | > 1.82 | 3.65 | > 7.30 | < 0.002 | - | - |
| Fungi | |||||||
| Candida albicans ATTC 10231 | > 1.82 | > 1.82 | 3.65 | > 7.30 | - | < 0.001 | - |
| Candida glabrata ATCC 2001 | > 1.82 | > 1.82 | 3.65 | > 7.30 | - | < 0.001 | - |
| Candida parapsilosis ATCC 22019 | > 1.82 | > 1.82 | 3.65 | > 7.30 | - | < 0.001 | - |