TABLE 2.

Reagent associated with ferroptosis.

Reagent	Target/function	Impact on ferroptosis	Mechanism
Selenium	Selenoproteins, GPX4	Stimulates the expression of the selenoproteins, such as antioxidant GPX4	GPX4 availability
DFX	Iron	Function as iron chelator, depletes iron, and prevent iron-dependent lipid peroxidation	Reduced iron overload
VK-28	Iron	Function as iron chelator, depletes iron, and prevent iron-dependent lipid peroxidation	Reduced iron overload
Deferiprone	Iron	Function as iron chelator, depletes iron, and prevent iron-dependent lipid peroxidation	Reduced iron overload
LOX inhibitors	Lipid peroxidation	Inhibits cytosolic ROS production and blocks lipid peroxidation	Radical trapping
Ebselen (DMT1 inhibitors)	Iron	Reduced the iron ion transport activity of DMT1 and prevents iron-dependent lipid peroxidation	Reduced iron overload