TABLE 2.

Spearman’s rank correlation coefficients (with 95% C.I. and p-values) between epigenetic age acceleration and continuous health outcomes. Significant results with p < 0.05/(25 × 5) = 4.0E-4 were highlighted in bold font.

12 continuous health outcomes	HannumEAA (s.d. = 3.63 years)				IEAA (s.d. = 3.69 years)				PhenoEAA (s.d. = 4.79 years)				GrimEAA (s.d. = 3.43 years)				DunedinPACE (s.d. = 0.1064)
	Spearman’s correlation	95% CI		p-value	Spearman’s correlation	95% CI		p-value	Spearman’s correlation	95% CI		p-value	Spearman’s correlation	95% CI		p-value	Spearman’s correlation	95% CI		p-value
Body mass index	0.089	0.050	0.128	9.8E-06	0.058	0.019	0.098	3.7E-03	0.115	0.076	0.154	1.1E-08	0.115	0.076	0.154	1.0E-08	0.238	0.200	0.275	4.1E-33
Body fat percentage	0.084	0.044	0.124	3.7E-05	0.046	0.006	0.086	2.3E-02	0.101	0.061	0.140	7.9E-07	0.104	0.064	0.144	3.6E-07	0.217	0.178	0.255	7.8E-27
Waist circumference	0.084	0.044	0.123	3.2E-05	0.048	0.009	0.087	1.7E-02	0.106	0.066	0.144	1.5E-07	0.110	0.071	0.149	4.1E-08	0.209	0.171	0.247	8.4E-26
Fasting glucose	−0.011	−0.051	0.028	5.8E-01	−0.025	−0.064	0.015	2.2E-01	−0.029	−0.069	0.010	1.5E-01	−0.049	−0.088	−0.010	1.5E-02	−0.109	−0.148	−0.070	5.3E-08
HbA1c	0.014	−0.026	0.053	4.9E-01	−0.010	−0.050	0.029	6.2E-01	0.014	−0.026	0.053	4.9E-01	0.003	−0.037	0.042	8.9E-01	−0.019	−0.059	0.020	3.4E-01
Diastolic blood pressure	0.026	−0.013	0.066	1.9E-01	0.056	0.017	0.095	5.4E-03	0.025	−0.015	0.064	2.2E-01	0.007	−0.032	0.047	7.2E-01	0.017	−0.022	0.057	3.9E-01
Systolic blood pressure	0.026	−0.013	0.066	1.9E-01	0.031	−0.009	0.070	1.3E-01	0.011	−0.029	0.050	5.9E-01	0.017	−0.023	0.056	4.1E-01	0.023	−0.017	0.062	2.6E-01
Triglyceride	0.020	−0.020	0.059	3.3E-01	−0.008	−0.048	0.031	6.8E-01	0.027	−0.013	0.066	1.9E-01	−0.014	−0.053	0.026	5.0E-01	0.026	−0.013	0.066	1.9E-01
LDL-C	−0.016	−0.055	0.024	4.3E-01	−0.016	−0.055	0.024	4.4E-01	−0.023	−0.062	0.017	2.6E-01	−0.009	−0.049	0.030	6.5E-01	−0.039	−0.079	0.000	5.1E-02
HDL-C	−0.043	−0.082	−0.003	3.5E-02	−0.013	−0.052	0.027	5.3E-01	−0.039	−0.078	0.001	5.4E-02	−0.068	−0.107	−0.029	7.0E-04	−0.131	−0.170	−0.092	6.5E-11
TG/HDL-C ratio	0.029	−0.010	0.069	1.5E-01	−0.009	−0.048	0.031	6.6E-01	0.035	−0.005	0.074	8.5E-02	−0.022	−0.061	0.018	2.8E-01	0.029	−0.011	0.068	1.6E-01
Forced vital capacity	−0.020	−0.069	0.030	4.3E-01	−0.003	−0.052	0.046	9.1E-01	0.004	−0.045	0.054	8.6E-01	−0.004	−0.054	0.045	8.7E-01	−0.003	−0.053	0.046	8.9E-01