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. 2023 Feb 4;13:100268. doi: 10.1016/j.jvacx.2023.100268

Table 1.

Pre-Specified Outcomes after MMR Administration.a

Outcome Diagnosis Setting Risk Window Control Windowb ICD-9-CM Codesc ICD-10-CM Codesd
Serious Outcomese
Anaphylaxis ED, IP 0–2 days 10–12 days 995.0, 999.42 T78.2*, T80.52*, T88.6*
Encephalitis/Myelitis ED, IP 1–42 days 50–91 days 055.0, 056.01, 072.2, 323.5*, 323.6*, 323.8*, 323.9, 348.30 B05.0, B06.01, B26.2, G04.0*, G04.3*, G04.8*, G04.9*, G05.3, G05.4, G93.40
GBS ED, IP, OP 1–42 days 50–91 days 357.0 G61.0
ITP ED, IP, OP 1–42 days 50–91 days 287.31 D69.3
Meningitis ED, IP 1–42 days 50–91 days 047.9, 055.79, 056.09, 072.1, 322.0 A87.9, B05.1, B06.02, B26.1, G03.0
Seizure ED, IP 0–42 days 50–92 days 345.80, 780.31, 780.32, 780.39 G40.50*, G40.89, R56.0*, R56.9
Non-Serious Outcomes
Allergic Reaction ED, IP, OP 0–2 days 10–12 days 708.0, 708.1, 708.9, 995.1, 995.21, 995.27, 995.3 L50.0, L50.1, L50.9, T78.3*, T78.4*
Arthropathy ED, IP, OP 6–14 days 22–30 days 716.4*, 716.5*, 716.6*, 716.9*, 719.4*, 719.5* M12.9, M13.0, M13.1*, M25.5*, M25.6*
Fever ED, IP, OP 6–14 days 22–30 days 780.60, 780.61, 780.62, 780.63 R50.81, R50.82, R50.83, R50.9
Injection Site Reaction ED, IP, OP 1–6 days 14–19 days 680.3, 680.9, 682.3, 682.8, 682.9, 686.9, 729.5, 729.81 L02.413, L02.414, L02.419, L02.423, L02.424, L02.429, L02.433, L02.434, L02.439, L02.9*, L03.113, L03.114, L03.119, L03.123, L03.124, L03.129, L03.818, L03.898, L03.9*, L08.9, M79.601, M79.602, M79.603, M79.609, M79.62*, M79.63*, M79.89
Lymphadenopathy ED, IP, OP 6–14 days 22–30 days 289.3, 683, 785.6 I88.8, I88.9, L04.2, L04.8, L04.9, R59.*
Non-Specific Reaction ED, IP, OP 0–6 days 14–20 days 979.4, 979.6, 979.9, 995.20, 995.29, 999.39, 999.9, E949.4, E949.6, E949.9 T50.901*, T50.905*, T50.991*, T50.995*, T50.B91*, T50.B95*, T50.Z91*, T50.Z95*, T78.8*, T80.29*, T88.0*, T88.1*, T88.7*, T88.9*
Parotitis ED, IP, OP 6–14 days 22–30 days 527.2 K11.20, K11.21
Rash ED, IP, OP 6–14 days 22–30 days 782.1 R21
Syncope ED, IP, OP Day 0 Day 8 458.29, 458.8, 458.9, 780.2 I95.2, I95.8*, I95.9, R55

Abbreviations: MMR = measles, mumps, and rubella vaccine; ED = emergency department; IP = inpatient; OP = outpatient; ICD-9-CM = International Classification of Diseases, Ninth Revision, Clinical Modification; ICD-10-CM = International Classification of Diseases, Tenth Revision, Clinical Modification; *=wildcard; GBS = Guillain-Barré syndrome; ITP = immune thrombocytopenia.

a

For all pre-specified outcomes, events were considered incident if the diagnosis code that appeared in the post-vaccination window was the first occurrence of a diagnosis code for that outcome in 60 days.

b

Control windows were designed to be the same length (i.e., number of days) as the risk windows, with a washout period of 7 days between the risk window and control window.

c

ICD-9-CM were used to identify outcomes prior to October 1, 2015.

d

ICD-10-CM were used to identify outcomes on or after October 1, 2015.

e

Medical record reviews were conducted for all serious outcomes to confirm electronic diagnoses.