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. 2023 Jan 25;14:100196. doi: 10.1016/j.jpi.2023.100196

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — Cluster analysis of ccRCC, ChRCC, and PRCC. (A) Representative region of interest from cores analyzed in CytoMap. Columns 1 and 2 show corresponding H&E and IHC images after co-registration. The distance between the H&E and IHC tissue sections hinders a direct comparison at the cell level. The IHC image is analyzed in QuPath as described in Fig. 2 to identify the NF1 class of each cell (third column). Fourth column shows the CytoMap cluster designation of each cell in the tissue context. (B) NF1 intensity comparison among clusters. Box plots show the NF1 staining intensity in each cluster. (C) Cluster representation inside NF1 classes. The percentage of cells within each cluster is plotted on the y-axis for NF1-negative, NF1-low, and NF1-high classes (X-axis). Tissue images are screenshots at 40X magnification in QuPath.