Table 1.
Summary of apparent dissociation constants for MLL1 core complex assembly at different temperaturesa
| Temperature (°C) | Kdapp (nM) | Confidence interval (1σ) |
|---|---|---|
| 5 | 7 | 6–9 |
| 10 | 7 | 5–11 |
| 15 | 20 | 13–30 |
| 20 | 30 | 22–39 |
| 25 | 62 | 51–72 |
| 30 | 290 | 204–417 |
| 37 | 6200 | 4900–7900 |
Dissociation constants and error estimates were obtained from fitting MWRAD2 concentration versus signal weight-average sedimentation coefficient (sw) using the A + B ⇋ AB heteroassociation model in SEDPHAT (59).