Table 2.

Hazard Ratios (95% CI) of CVD, CHD, and Stroke, Stratified by METS-IR

Exposure	Model 1	Model 2	Model 3
	(HR, 95% CI)	(HR, 95% CI)	(HR, 95% CI)
CVD
Per SD increment	1.35 (1.19, 1.52)	1.34 (1.18, 1.52)	1.30 (1.16, 1.47)
Tertiles
T1 (<42.01)	Reference	Reference	Reference
T2 (≥42.02 to <48.25)	1.38 (0.99, 1.92)	1.35 (0.97, 1.88)	1.32 (0.95, 1.83)
T3 (≥48.26)	2.28 (1.66, 3.12)	2.21 (1.61, 3.04)	2.05 (1.52, 2.77)
P for trend	<0.001	<0.001	<0.001
Categories
T1–2 (<48.25)	Reference	Reference	Reference
T3 (≥48.26)	1.91 (1.49, 2.45)	1.88 (1.46, 2.41)	1.78 (1.40, 2.25)
CHD
Per SD increment	1.36 (1.17, 1.59)	1.34 (1.14, 1.57)	1.32 (1.14, 1.53)
Tertiles
T1 (<42.01)	Reference	Reference	Reference
T2 (≥42.02 to <48.25)	1.28 (0.84, 1.93)	1.24 (0.82, 1.87)	1.26 (0.84, 1.89)
T3 (≥48.26)	2.15 (1.45, 3.19)	1.98 (1.33, 2.96)	1.96 (1.35, 2.84)
P for trend	<0.001	<0.001	<0.001
Categories
T1–2 (<48.25)	Reference	Reference	Reference
T3 (≥48.26)	1.88 (1.38, 2.58)	1.77 (1.29, 2.44)	1.74 (1.29, 2.34)
Stroke
Per SD increment	1.33 (1.09, 1.63)	1.36 (1.11, 1.66)	1.27 (1.05, 1.54)
Tertiles
T1 (<42.01)	Reference	Reference	Reference
T2 (≥42.02 to <48.25)	1.60 (0.92, 2.78)	1.61 (0.92, 2.82)	1.43 (0.83, 2.47)
T3 (≥48.26)	2.57 (1.52, 4.34)	2.69 (1.58, 4.56)	2.24 (1.35, 3.72)
P for trend	<0.001	<0.001	<0.001
Categories
T1–2 (<48.25)	Reference	Reference	Reference
T3 (≥48.26)	1.99 (1.32, 2.98)	2.06 (1.37, 3.11)	1.85 (1.25, 2.74)

Notes: Model 1: adjusted for age and sex. Model 2: adjusted for variables in model 1 plus drinking status, history of diabetes, smoking status, DBP, and SBP. Model 3: adjusted for variables in model 2 plus eGFR, TC, LDL-C, FBG, AHI, ACEIs/ARBs, β-Blockers, CCBs, diuretics, and OSA therapy.

Abbreviations: HR, hazard ratio; CI, confidence interval; CVD, cardiovascular disease; CHD, coronary heart disease; METS-IR, metabolic score for insulin resistance.