Table 4.
Major congenital malformations (n = number of pregnancies per group); Marked cases have been exposed to co-reported teratogens.
| Major congenital malformation | Stopped (group A); (n = 69) | Continued (group B); (n = 21) |
|---|---|---|
| CNS anomalies (n) | ||
| Arnold-Chiari malformation type I (1) | ||
| Hydrocephalusa (1) | ||
| Cardiovascular anomalies | ||
| ASD + patent ductus arteriosus (1) | Ebstein’s anomaly + patent ductus arteriosus (1) | |
| VSD + patent foramen ovaleb (1) | ||
| Multiple malformations | ||
| Pyelocaliectasis + spinal cord anomalyb (1) | Hydrops fetalis + torticollis (1) | |
| Dandy-walker syndrome + unspecified cardiac anomaly (1) | ||
| Mega cisterna magna + patent foramen ovale (1) | ||
| Positional plagiocephaly + rectal fistulac (1) | ||
| Kidney enlargement + short stature + rotund torso (1) | ||
| VSD + hydronephrosis (1) | ||
| Total, n (%) | 10 (14.5%) | 2 (9.5%) |
ASD: Atrial septal defect; VSD: ventricular septal defect.
aPlacental insufficiency resulted in stillbirth.
bBoth exposed to methotrexate.
cIn premature newborn, twin pregnancy.