Fig. 2.

Open Field Test (OFT). Mice were allowed to roam freely in a clear Plexiglas open field arena for 60 min. Mean ± standard error shown for total ambulatory movement stratified by sex (A, B: treatment by sex interaction P = 0.020 and 0.001, respectively), total number of rearings defined as the number of times the mouse disrupted two infrared beams by standing on its hind limbs (C, D; treatment P = 0.033 and 0.127, respectively), and (E, F) time spent in the center zone of the arena (E, F; treatment P = 0.378 and 0.174, respectively) (n = 111). Significant post-hoc pairwise treatment by sex by time bin contrasts shown for repeated measures models (^†P < 0.05; *P < 0.05 following Bonferroni correction).