Table 2.
List of SARS-CoV-2 N-protein mutations identified from Indian isolates
| S. no. | Mutation | Polarity change | Charge change | ΔΔG value, Kcal/mol | Provean score | Effect on protein function |
|---|---|---|---|---|---|---|
| 1 | D3Y | P to P | Acidic to Neutral | 0.02 | –0.103 | Neutral |
| 2 | D3L | P to NP | Acidic to Neutral | 0.34 | –0.230 | Neutral |
| 3 | P6T | NP to P | Neutral to Neutral | –1.10 | –0.223 | Neutral |
| 4 | Q9H | P to P | Neutral to Basic (weakly) | –0.90 | –0.210 | Neutral |
| 5 | A12T | NP to P | Neutral to Neutral | –0.72 | –0.473 | Neutral |
| 6 | P13L | NP to NP | Neutral to Neutral | –0.48 | –1.230 | Neutral |
| 7 | P13S | NP to P | Neutral to Neutral | –1.63 | –0.913 | Neutral |
| 8 | G18V | NP to NP | Neutral to Neutral | –0.67 | –0.462 | Neutral |
| 9 | G18S | NP to P | Neutral to Neutral | –1.37 | 0.046 | Neutral |
| 10 | D22Y | P to P | Acidic to Neutral | –0.36 | –1.253 | Neutral |
| 11 | D22N | P to P | Acidic to Neutral | –1.40 | –0.541 | Neutral |
| 12 | G30R | NP to P | Neutral to Basic(strongly) | –0.54 | –0.455 | Neutral |
| 13 | E31Q | P to P | Acidic to Neutral | –0.70 | 0.054 | Neutral |
| 14 | S33I | P to P | Neutral to Neutral | 0.27 | –1.372 | Neutral |
| 15 | S33G | P to NP | Neutral to Neutral | –1.08 | –0.328 | Neutral |
| 16 | G34W | NP to NP | Neutral to Neutral | –0.13 | –1.609 | Neutral |
| 17 | N49S | P to P | Neutral to Neutral | –0.82 | –0.047 | Neutral |
| 18 | P67S | NP to P | Neutral to Neutral | –1.51 | –1.465 | Neutral |
| 19 | V72L | NP to NP | Neutral to Neutral | –1.22 | –2.419 | Neutral |
| 20 | A90S | NP to P | Neutral to Neutral | –0.81 | 0.680 | Neutral |
| 21 | R92S | P to P | Basic (strongly) to Neutral | –1.23 | –3.718 | Deleterious |
| 22 | G97S | NP to P | Neutral to Neutral | –1.33 | –1.980 | Neutral |
| 23 | A119S | NP to P | Neutral to Neutral | –0.86 | –1.628 | Neutral |
| 24 | G120R | NP to P | Neutral to Basic (strongly) | –0.29 | –0.733 | Neutral |
| 25 | D128Y | P to P | Acidic to Neutral | 0.23 | –4.529 | Deleterious |
| 26 | A134V | NP to NP | Neutral to Neutral | –0.12 | –2.811 | Deleterious |
| 27 | T135I | P to NP | Neutral to Neutral | –0.42 | –1.410 | Neutral |
| 28 | L139F | NP to NP | Neutral to Neutral | –0.85 | –0.697 | Neutral |
| 29 | D144G | P to NP | Acidic to Neutral | –0.85 | 1.019 | Neutral |
| 30 | D144Y | P to P | Acidic to Neutral | 0.20 | –1.764 | Neutral |
| 31 | A152S | NP to P | Neutral to Neutral | –0.92 | 1.463 | Neutral |
| 32 | A156S | NP to P | Neutral to Neutral | –0.83 | –0.457 | Neutral |
| 33 | Q163K | P to P | Neutral to Basic | –0.40 | –0.060 | Neutral |
| 34 | S180I | P to NP | Neutral to Neutral | –0.14 | –3.465 | Deleterious |
| 35 | R191L | P to NP | Basic (strongly) to Neutral | –0.58 | –3.269 | Deleterious |
| 36 | S193I | P to NP | Neutral to Neutral | –0.36 | –2.755 | Deleterious |
| 37 | S194L | P to NP | Neutral to Neutral | –0.38 | –4.272 | Neutral |
| 38 | P199S | NP to P | Neutral to Neutral | –1.48 | –0.334 | Neutral |
| 39 | P199L | NP to NP | Neutral to Neutral | –0.72 | –2.057 | Neutral |
| 40 | S202I | P to NP | Neutral to Neutral | –0.11 | –3.308 | Neutral |
| 41 | S202N | P to P | Neutral to Neutral | –0.78 | –0.404 | Deleterious |
| 42 | R203K | P to P | Basic (strongly) to Basic | –0.93 | –1.604 | Neutral |
| 43 | R203M | P to NP | Basic (strongly) to Neutral | –0.73 | –3.304 | Deleterious |
| 44 | G204R | NP to P | Neutral to Basic (strongly) | –0.52 | –1.656 | Neutral |
| 45 | G204T | NP to P | Neutral to Neutral | –0.96 | –1.760 | Neutral |
| 46 | T205I | P to NP | Neutral to Neutral | –0.53 | –1.562 | Neutral |
| 47 | R209I | P to NP | Basic (strongly) to Neutral | –0.18 | 2.455 | Neutral |
| 48 | R209K | P to P | Basic (strongly) to Basic | –0.69 | –0.504 | Neutral |
| 49 | M210I | NP to NP | Neutral to Neutral | –0.73 | –0.665 | Neutral |
| 50 | A218V | NP to NP | Neutral to Neutral | 0.21 | 0.171 | Neutral |
| 51 | D225Y | P to P | Acidic to Neutral | –0.08 | –1.793 | Neutral |
| 52 | M234I | NP to NP | Neutral to Neutral | –0.03 | 0.044 | Neutral |
| 53 | S235F | P to NP | Neutral to Neutral | 0.76 | –1.738 | Neutral |
| 54 | G236C | NP to NP | Neutral to Neutral | –0.27 | –2.269 | Neutral |
| 55 | G238S | NP to P | Neutral to Neutral | –0.54 | 0.851 | Neutral |
| 56 | Q239R | P to P | Neutral to Basic (strongly) | 0.17 | –0.478 | Neutral |
| 57 | A251T | NP to P | Neutral to Neutral | –0.42 | –1.593 | Neutral |
| 58 | A252V | NP to NP | Neutral to Neutral | –0.25 | –1.418 | Neutral |
| 59 | V270L | NP to NP | Neutral to Neutral | –0.69 | –2.484 | Neutral |
| 60 | H300Y | P to P | Basic (weakly) to Neutral | 0.46 | –1.577 | Neutral |
| 61 | P302S | NP to P | Neutral to Neutral | –1.30 | –4.043 | Deleterious |
| 62 | M317I | NP to NP | Neutral to Neutral | –0.86 | –0.965 | Neutral |
| 63 | S327L | P to NP | Neutral to Neutral | 0.44 | –3.022 | Deleterious |
| 64 | T332N | P to P | Neutral to Neutral | –0.76 | –1.385 | Neutral |
| 65 | Y333H | P to P | Neutral to Basic(weakly) | –1.10 | –3.913 | Deleterious |
| 66 | P344S | NP to P | Neutral to Neutral | –1.46 | –4.031 | Deleterious |
| 67 | D348Y | P to P | Acidic to Neutral | –0.41 | –0.588 | Neutral |
| 68 | A359S | NP to P | Neutral to Neutral | –0.86 | –1.414 | Neutral |
| 69 | T362I | P to NP | Neutral to Neutral | –0.35 | –1.722 | Neutral |
| 70 | P364L | NP to NP | Neutral to Neutral | –0.33 | –2.424 | Neutral |
| 71 | P368L | NP to NP | Neutral to Neutral | –0.25 | –1.406 | Neutral |
| 72 | K374N | P to P | Basic to Neutral | –0.10 | –0.626 | Neutral |
| 73 | D377Y | P to P | Acidic to Neutral | 0.21 | –1.779 | Neutral |
| 74 | T379I | P to NP | Neutral to Neutral | –0.15 | –0.648 | Neutral |
| 75 | R385I | P to NP | Basic (weakly) to Neutral | 0.64 | –0.578 | Neutral |
| 76 | Q389H | P to P | Neutral to Basic (weakly) | –0.40 | –1.114 | Neutral |
| 77 | Q390L | P to NP | Neutral to Neutral | 0.26 | –0.983 | Neutral |
| 78 | T393I | P to NP | Neutral to Neutral | 0.10 | –0.613 | Neutral |
| 79 | D399Y | P to P | Acidic to Neutral | 0.26 | –0.599 | Neutral |
| 80 | D401Y | P to P | Acidic to Neutral | 0.06 | –0.717 | Neutral |
| 81 | Q409L | P to NP | Neutral to Neutral | 0.11 | –0.200 | Neutral |