Figure 1.

Features (APD90, qNet, and CaD90) as a function of drug concentrations for hydroxychloroquine, diltiazem, and combined hydroxychloroquine-diltiazem. Panel (A) shows the result of APD90, panel (B) for qNet, and panel (C) for CaD90. The labels in $\mathrm{x}$ axis represent the concentration of each compound incorporated in the simulation. For example, $3\times \mathrm{cmax}$ for the combination of compound A and B means that the concentration for each A and B is $3\times \mathrm{cmax}$. Furthermore, in a single box plot, the cross line refers to the average value of the feature; the lower, middle, and upper lines of the box refer to the first quartile, median, and third quartile, respectively; the upper and lower lines outside the box refer to maximum and minimum values excluding the outliers; circles represent the outliers.